The molecular weight is approximately 23.6 kDa and will have a range of 23,000 - 26,000. There are a number of publications available on the structure, please check the literature for additional information.
C6780
α-Casein from bovine milk
≥70% αs-casein basis (electrophoresis), lyophilized powder
Synonym(s):
alpha-S1-casein, alpha-S2-casein
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| Size/SKU | Availability | Price |
|---|---|---|
250 mg | Available to ship TODAYfromMILWAUKEE | $97.90 |
1 g | Check Cart for Availability | $287.00 |
5 g | Check Cart for Availability | $1,140.00 |
About This Item
Form:
lyophilized powder
Assay:
≥70% αs-casein basis (electrophoresis)
Biological source:
bovine milk
biological source
bovine milk
Quality Segment
assay
≥70% αs-casein basis (electrophoresis)
form
lyophilized powder
technique(s)
mass spectrometry (MS): suitable
storage temp.
−20°C
SMILES string
[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C
InChI
1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)
InChI key
BECPQYXYKAMYBN-UHFFFAOYSA-N
Gene Information
cow ... CSN1(282208), CSN1S2(282209)
Application
α-Casein from bovine milk is an Immunoglobulin E (IgE)-binding epitope belonging to the Casein phosphoprotein family. It has been used in studies of children with insulin-dependent diabetes mellitus (IDDM), due to the strong cross-reactivity of α-casein antibodies with insulin. Studies of children displaying (IDDM) show higher levels of α-casein antibodies than control siblings, which may serve as a risk marker for IDDM.
Biochem/physiol Actions
α-Casein can be an immunogen in young children, and anti-a-casein antibodies have strong cross-reactivity with insulin. This effect can explain the uncommon insulin autoimmunity, but it does not appear to progress to Type I diabetes.
Preparation Note
Chromatographically purified
1 of 1
This Item | |||
|---|---|---|---|
| description ≥70% αs-casein basis (electrophoresis), lyophilized powder | description BioUltra, ≥98% (PAGE) | description ≥70% (PAGE), lyophilized powder | description BioReagent, suitable for insect cell culture |
| biological source bovine milk | biological source bovine milk | biological source bovine milk | biological source bovine milk |
| technique(s) mass spectrometry (MS): suitable | technique(s) activity assay: suitable | technique(s) isoelectric focusing (IEF): suitable | technique(s) cell culture | insect: suitable |
| assay ≥70% αs-casein basis (electrophoresis) | assay ≥98% (PAGE) | assay ≥70% (PAGE) | assay - |
| form lyophilized powder | form essentially salt-free, lyophilized powder | form lyophilized powder | form powder |
| Gene Information cow ... CSN1(282208), CSN1S2(282209) | Gene Information bovine ... CSN2(281099), CSN3(281728) | Gene Information cow ... MKCAS(100531419), MKCASP(105755569) | Gene Information bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099), CSN3(281728) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. - |
Storage Class
11 - Combustible Solids
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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