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C7521

Human Collagen Type IV

from human placenta, powder, suitable for substrate for collagenase and for diagnostic assay manufacturing

Synonym(s):

Collagen Type 4

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$206.00
10 mg

Available to ship TODAYfromMILWAUKEE

$342.00
50 mg

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$1,270.00

About This Item

CAS Number:
9007-34-5
UNSPSC Code:
12352202
NACRES:
NA.54
EC Number:
232-697-4
MDL number:
MFCD00130825
Biological source:
human placenta

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Product Name

Collagen from human placenta, Bornstein and Traub Type IV, powder

biological source

human placenta

Quality Segment

description

Sigma Type VI

form

powder

impurities

HIV, hepatitis B and hepatitis C, none detected

solubility

0.5 M acetic acid: 1 mg/mL

suitability

suitable for substrate for collagenase

UniProt accession no.

application(s)

diagnostic assay manufacturing

storage temp.

−20°C

Gene Information

Biochem/physiol Actions

During development, collagen IV is ubiquitously distributed in BMs. During the maturation process, this network gets partially replaced in a remarkably tissue specific manner, defining BM structure and function. Collagen IV has been shown to bind to platelets, hepatocytes, keratinocytes, endothelial, mesangial, pancreatic cells and some tumor cells.

Preparation Note

This is a lyophilized powder that can be reconstituted in sterile .5 M acetic acid, PBS or water at 1 mg/mL. A PBS solution will be stable for at least one year at -20°C. It is prepared by a modification of the pepsin extraction method of Glanville, R.W., et al.

Analysis Note

An SDS polyacrylamide gel electrophoresis test run under reducing conditions consistent with basement membrane collagen yields three major bands.

Other Notes

All collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type IV collagen occurs only in the basement membranes and contains up to six genetically distinct a-chains.
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Be wary of confusing Sigma-type designations with recognized collagen classification types.

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Collagen from human placenta Bornstein and Traub Type IV, powder

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Sigma-Aldrich

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Collagen from human placenta

Collagen from human placenta Bornstein and Traub Type IV, powder

Sigma-Aldrich

C8374

Collagen from human placenta

description

Bornstein and Traub Type IV, powder

description

Bornstein and Traub Type IV, solution, suitable for cell culture, High Performance

description

Bornstein and Traub Type IV, powder, BioReagent, suitable for cell culture

description

Bornstein and Traub Type IV, powder

biological source

human placenta

biological source

human placenta

biological source

human placenta

biological source

human placenta

Gene Information

human ... COL4A2(1284), COL4A3(1285), COL4A4(1286), COL4A5(1287), COL4A6(1288)

Gene Information

human ... COL4A1(1282), COL4A2(1284), COL4A3(1285), COL4A4(1286), COL4A5(1287), COL4A6(1288)

Gene Information

human ... COL4A1(1282), COL4A2(1284), COL4A3(1285), COL4A4(1286), COL4A5(1287), COL4A6(1288)

Gene Information

human ... COL4A1(1282), COL4A2(1284), COL4A3(1285), COL4A4(1286), COL4A5(1287), COL4A6(1288)

form

powder

form

solution

form

powder

form

powder

application(s)

diagnostic assay manufacturing

application(s)

-

application(s)

-

application(s)

-

suitability

suitable for substrate for collagenase

suitability

-

suitability

-

suitability

-

UniProt accession no.

P08572, P53420, Q01955, Q14031, P29400

UniProt accession no.

P53420, Q14031, P29400, P02462, Q01955, P08572

UniProt accession no.

Q01955, P08572, P53420, Q14031, P02462, P29400

UniProt accession no.

P53420, P02462, Q14031, P29400, P08572, Q01955

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Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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