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F1168

Fibroblast Growth Factor-9 human

Name: Fibroblast Growth Factor-9 human
Brand: SIGMA
Price: 317 CHF

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

Synonym(e):

hGFG-9, FGF-9, GAF, Glial Activating Factor

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Packungsgröße	SKU	Verfügbarkeit	Preis
25 μg		Warenkorb auf Verfügbarkeit prüfen	CHF 317.00

Über diesen Artikel

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00677010

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf21 cells

Assay:

≥97% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

~25 kDa

Impurities:

endotoxin, tested

CHF 317.00

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Eigenschaften

Produktname

Fibroblast Growth Factor-9 human, recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)

biological source

human

Quality Segment

100

recombinant

expressed in baculovirus infected Sf21 cells

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

2.6 ng/mL

mol wt

~25 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P31371

storage temp.

−20°C

Gene Information

human ... FGF9(2254)

Beschreibung

General description

FGF9 (fibroblast growth factor 9) is a member of the FGF family, which consists of a minimum of 24 members. This protein is highly conserved across species, and the gene is localized to human chromosome 13q11-q12. In embryos, FGF9 mRNA has a ubiquitous expression pattern. In adults, this protein has a limited range of expression in normal conditions, and expression is usually restricted to brain, kidney and uterus.[1]

Application

FGF9 (fibroblast growth factor 9) has been used for the culture of embryonic Sertoli cells obtained from E14.5 testes.[2]

Biochem/physiol Actions

FGF9 (fibroblast growth factor 9) is expressed in the epithelium and mesothelium of developing lung in the pseudoglandular stage. In developing lungs, it regulates the branching of epithelium, proliferation of mesenchymal cells, and expansion of the lungs. It is overexpressed in patients with idiopathic pulmonary fibrosis (IPF), in regions demonstrating active cell hyperplasia, metaplasia and fibrosis. Thus, it might facilitate the pathogenesis of IPF.[3] The expression of this protein is up-regulated in colon cancer, which is an outcome of hypoxia-induced translational activation.[1]

Mitogenic for glial cells, fibroblasts, and oligodendrocyte type 2 astrocyte progenitor cells; not mitogenic for endothelial cells. Like aFGF and bFGF, FGF-9 has no secretory signal sequence.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured in a bioassay using BALB/3T3 cells.

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Dieser Artikel	F5542	F8424	F5392
Sigma-Aldrich F1168 Fibroblast Growth Factor-9 human	Sigma-Aldrich F5542 Fibroblast Growth Factor-Acidic human	Sigma-Aldrich F8424 Fibroblast Growth Factor-4 human	Sigma-Aldrich F5392 Fibroblast Growth Factor-Basic from bovine pituitary
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ~90% (SDS-PAGE and N-terminal analysis)
recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant -
biological source human	biological source human	biological source human	biological source bovine pituitary glands
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
F1168-25UG	04061833611739

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