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F2677

Furin human

≥2,000 unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells

Synonym(s):

Dibasic-processing enzyme, Furin convertase, PACE, Paired basic amino acid residue-cleaving enzyme

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Size/SKUAvailabilityPrice
50 units
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$806.00

About This Item

UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
MFCD03456906
Recombinant:
expressed in baculovirus infected Sf9 cells
Concentration:
≥2,000 unit/mL

$806.00

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recombinant

expressed in baculovirus infected Sf9 cells

Quality Segment

200

form

buffered aqueous solution

mol wt

57 kDa

concentration

≥2,000 unit/mL

UniProt accession no.

P09958

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FURIN(5045)

Application

Furin is capable of cleaving precursors of a wide variety of proteins, including growth factors, serum proteins, including proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins, and bacterial exotoxins, typically at sites marked by the consensus sequence Arg-Xaa-(Lys/Arg)-Arg.[1]

Biochem/physiol Actions

Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells.
Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It has a molecular mass of 52.7 kDa. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells.[2] Furin cleaves precursor proteins at their paired basic amino acid processing sites. Some substrates of furin include von Willebrand factor, transforming growth factor beta 1 precursor, pro-beta-secretase and proparathyroid hormone.

Physical form

Solution in 10 mM MES, pH 7.0 at 25 °C, 1 mM CaCl2, 50% glycerol.

Preparation Note

Isolated from Spodoptera frugiperda (Sf9) cells infected with recombinant baculovirus carrying truncated human furin

Other Notes

One unit is defined as the amount of enzyme required to cleave 25 μg of a MBP-FN-paramyosin-ΔSal substrate to 95% completion in 6 hours at 25°C in a total reaction volume of 25 μl.

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MABS1812MHPA067869SRP6274
Furin human ≥2,000 unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells

Sigma-Aldrich

F2677

Furin human

Anti-Furin Antibody, clone 16B1.1 clone 16B1.1, from mouse

Sigma-Aldrich

MABS1812M

Anti-Furin Antibody, clone 16B1.1

Anti-FURIN antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA067869

Anti-FURIN antibody produced in rabbit

Furin human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sigma-Aldrich

SRP6274

Furin human

description

≥2,000 unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells

description

clone 16B1.1, from mouse

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Gene Information

human ... FURIN(5045)

Gene Information

human ... FURIN(5045)

Gene Information

human ... FURIN(5045)

Gene Information

human ... PACE(5045)

form

buffered aqueous solution

form

-

form

buffered aqueous glycerol solution

form

lyophilized powder

concentration

≥2,000 unit/mL

concentration

-

concentration

0.1 mg/mL

concentration

-

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

-

recombinant

-

recombinant

expressed in HEK 293 cells

storage temp.

−70°C

storage temp.

-

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P09958

UniProt accession no.

P09958

UniProt accession no.

-

UniProt accession no.

P09958

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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