Some cells, and in particular cancer cells, may be resistant to 5-fluorouracil. Please see this paper Huanwen, W., et al., Molecular Cancer, 8, 125 (2009) which addresses this observation, as well as references 16 and 30 in this publication.If the cells are treated with the closely related gemcitabine (Sigma-Aldrich Product G6423), and cell growth is not inhibited by that drug either, you will have shown that the "problem" is with the cell line, and not with the drug(s).
F8423
Fluorouracil
meets USP testing specifications
Synonym(s):
5-Fluorouracil, 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
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About This Item
Empirical Formula (Hill Notation):
C4H3FN2O2
CAS Number:
Molecular Weight:
130.08
UNSPSC Code:
12352207
NACRES:
NA.71
PubChem Substance ID:
EC Number:
200-085-6
Beilstein/REAXYS Number:
127172
MDL number:
Pricing and availability is not currently available.
Quality Segment
agency
USP/NF, meets USP testing specifications
mp
282-286 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
SMILES string
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
Gene Information
human ... TYMS(7298)
1 of 1
This Item | |||
|---|---|---|---|
| description meets USP testing specifications | description United States Pharmacopeia (USP) Reference Standard | description ≥99% (HPLC), powder | description analytical standard |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 100 |
| Gene Information human ... TYMS(7298) | Gene Information human ... TYMS(7298) | Gene Information human ... TYMS(7298) | Gene Information human ... TYMS(7298) |
| agency USP/NF, meets USP testing specifications | agency USP | agency - | agency - |
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) diagnostic assay manufacturing | application(s) cleaning products |
| mp 282-286 °C (dec.) (lit.) | mp 282-286 °C (dec.) (lit.) | mp 282-286 °C (dec.) (lit.) | mp 282-286 °C (dec.) (lit.) |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Why does the 5-Fluorouracil have no effect on my cell line, even at micromolar concentrations that should be more than high enough?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Do you have 5-FU (5-Fluorouracil) for injection? If not, how can I prepare it from the powder?
1 answer-
Sigma-Aldrich lists several fluorouracil products, but we do not offer Fluorouracil for injection. Our 5-Fluorouracil (5-FU) products cannot be given to human patients. (Note that although Product F8423 meets USP testing specifications, it is not a pharmaceutical grade or PharmaGrade product.)Having said that, a solution for injection into research animals could be prepared the same way as the Fluorouracil Injection, USP is. According to the drugs.com, "Fluorouracil Injection, USP, an antineoplastic anti-metabolite, is a colorless to yellow aqueous sterile, nonpyrogenic injectable solution for intravenous administration. Each mL contains: 50 mg fluorouracil; pH is adjusted to 8.6 to 9.4 with sodium hydroxide".
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