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G3295

GW0742

≥98% (HPLC), selective PPARδ agonist, powder

Synonym(s):

4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$267.00
5 mg

Available to ship TODAYfromMILWAUKEE

$911.00

About This Item

Empirical Formula (Hill Notation):
C21H17F4NO3S2
CAS Number:
Molecular Weight:
471.49
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$267.00


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Product Name

GW0742, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white

mp

134.5-135.5 °C

solubility

DMSO: >5 mg/mL, H2O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O

InChI

1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)

InChI key

HWVNEWGKWRGSRK-UHFFFAOYSA-N

Gene Information

Biochem/physiol Actions

GW0742 is a highly selective PPARδ agonist.
GW0742 is a highly selective PPARδ agonist. EC50 = 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

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This Item
M6191T2573R2408
description

≥98% (HPLC)

description

>98% (HPLC)

description

≥98% (HPLC)

description

-

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

>98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: insoluble, DMSO: >5 mg/mL

solubility

DMSO: 26 mg/mL, H2O: insoluble

solubility

DMSO: 20 mg/mL

solubility

DMSO: ≥10 mg/mL

color

white

color

white

color

white to off-white

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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