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G3643

α1-Acid Glycoprotein from bovine plasma

≥99%

Synonym(s):

Orosomucoid

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25 mg

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$361.00
100 mg
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250 mg

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About This Item

CAS Number:
66455-27-4
MDL number:
MFCD00133992
NACRES:
NA.61
UNSPSC Code:
12352202
Form:
powder
Assay:
≥99%
Biological source:
bovine plasma

$361.00

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biological source

bovine plasma

Quality Segment

assay

≥99%

form

powder

technique(s)

electrophoresis: suitable, mass spectrometry (MS): suitable

UniProt accession no.

storage temp.

2-8°C

Gene Information

bovine ... ORM1(497200)

General description

α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.
α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.

Application

α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine
α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
  • in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
  • for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
  • in the composition of tear model
  • as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)

Biochem/physiol Actions

α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).

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This Item
362199G9885112251
α1-Acid Glycoprotein from bovine plasma ≥99%

Sigma-Aldrich

G3643

α1-Acid Glycoprotein from bovine plasma

α2-HS-Glycoprotein, Human Plasma

Sigma-Aldrich

362199

α2-HS-Glycoprotein, Human Plasma

α1-Acid Glycoprotein from human plasma ≥99% (agarose gel electrophoresis)

Sigma-Aldrich

G9885

α1-Acid Glycoprotein from human plasma

α1-Acid Glycoprotein, Human Plasma

Sigma-Aldrich

112251

α1-Acid Glycoprotein, Human Plasma

description

≥99%

description

-

description

≥99% (agarose gel electrophoresis)

description

-

technique(s)

electrophoresis: suitable, mass spectrometry (MS): suitable

technique(s)

-

technique(s)

ELISA: suitable

technique(s)

-

biological source

bovine plasma

biological source

-

biological source

human plasma

biological source

human plasma

assay

≥99%

assay

≥90% (SDS-PAGE)

assay

≥99% (agarose gel electrophoresis)

assay

≥95% (SDS-PAGE)

form

powder

form

lyophilized

form

powder

form

lyophilized

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Gene Information

bovine ... ORM1(497200)

Gene Information

-

Gene Information

human ... ORM1(5004)

Gene Information

-

Storage Class

13 - Non Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000509938
    0000509940
    0000432611
    0000295980
    0000295977

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