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IL-4 mouse

Name: IL-4 mouse
Brand: SIGMA
Price: 191 USD
Availability: InStock

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-4, mIL-4, Interleukin-4 human

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Size/SKU	Availability	Price
5 μg	Available to ship TODAYfromMILWAUKEE	$191.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00166698

Biological source:

mouse

Recombinant:

expressed in E. coli

Assay:

≥98% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

~13.5 kDa

Impurities:

<0.1 EU/μg

$191.00

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Properties

Product Name

Interleukin-4 from mouse, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

mouse

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

0.1-2.0 ng/mL ED₅₀/EC₅₀

quality

endotoxin tested

mol wt

~13.5 kDa

packaging

pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg

UniProt accession no.

P07750

storage temp.

−20°C

Description

General description

Recombinant Interleukin‑4 from mouse (IL‑4; mIL‑4) is expressed in Escherichia coli and supplied as a lyophilized powder. IL‑4 is a lymphokine involved in the growth and differentiation of immune cells and is commonly used in mammalian cell culture research in vitro.

Application

Recombinant mouse IL‑4 has been used as a supplement in mammalian cell culture media, including class switch recombination assays and immune‑related in vitro research studies.

Biochem/physiol Actions

Interleukin‑4 (IL‑4) is an immunomodulatory cytokine that supports growth and differentiation of mmunologically competent cells. Recombinant mouse IL‑4 has been widely studied in cell‑based research models involving lymphocyte signaling, differentiation, and cytokine‑mediated cellular responses and VEGF‑induced and bFGF‑induced angiogenesis.

Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.

Interleukin-4, a lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and bFGF-induced angiogenesis. Human and mouse IL-4 share 50% amino acid sequence identity, but their biological actions are species-specific.

Physical form

Lyophilized, 0.2 μm filtered, with no additives.

Analysis Note

The proliferative activity is tested in culture using mouse HT-2 cells.

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This Item	I9646	I4144	I3650
Sigma-Aldrich I1020 Interleukin-4 from mouse	Sigma-Aldrich I9646 Interleukin-6 from mouse	Sigma-Aldrich I4144 Interleukin-3 from mouse	Sigma-Aldrich I3650 Interleukin-4 from rat
description IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free	description IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay ≥98% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥98% (SDS-PAGE)	assay ≥97% (SDS-PAGE)
biological source mouse	biological source mouse	biological source mouse	biological source rat
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
mol wt ~13.5 kDa	mol wt ~21.7 kDa	mol wt 15.1 kDa	mol wt predicted mol wt 13.5 kDa

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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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