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IL-6 human

Name: IL-6 human
Brand: SIGMA
Price: 370 USD
Availability: InStock

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-6 human, hIL-6, IL-6

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Size/SKU	Availability	Price
10 μg	Available to ship TODAYfromMILWAUKEE	$370.00
50 μg	Check Cart for Availability	$723.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00131403

Biological source:

human

Recombinant:

expressed in E. coli

Assay:

≥97% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

26 kDa

Impurities:

≤1.000 EU/μg

$370.00

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Properties

Product Name

Interleukin-6 human, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Segment

300

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

0.2-2.0 ng/mL ED₅₀/EC₅₀

quality

endotoxin tested

mol wt

26 kDa

packaging

pkg of 10 and 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1.000 EU/μg

color

white

UniProt accession no.

P05231

storage temp.

−20°C

Description

General description

Recombinant human Interleukin‑6 (IL‑6) is an immunomodulatory cytokine expressed in Escherichia coli and supplied as a lyophilized powder. IL‑6 is commonly used in mammalian cell culture research involving immune cell growth and activation studies in vitro.

Application

IL-6 has been used in mammalian cell culture research applications, including immune‑related cell signaling, activation, cytokine‑response studies in vitro, proliferation of T lymphocytes and hematopoietic progenitors.

Biochem/physiol Actions

Interleukin-6 (IL-6) is a multifunctional protein directly involved in the responses that occur after infection and is as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes.

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β₂), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffer saline (PBS), pH 7.4, containing 500 μg bovine serum albumin.

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This Item	SCU0001	SRP3096	I1646
Sigma-Aldrich I1395 Interleukin-6 human	Sigma-Aldrich SCU0001 Interleukin-6 human	Sigma-Aldrich SRP3096 Interleukin-6 human	Sigma-Aldrich I1646 Interleukin-3 human
description IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description recombinant, expressed in HEK 293 cells, suitable for cell culture	description Animal-component free, recombinant, expressed in E. coli, suitable for cell culture	description IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
assay ≥97% (SDS-PAGE)	assay ≥98% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥97% (HPLC and SDS-PAGE)
recombinant expressed in E. coli	recombinant expressed in HEK 293 cells	recombinant expressed in E. coli	recombinant expressed in E. coli
biological source human	biological source human	biological source human	biological source human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
Quality Level 300	Quality Level 200	Quality Level 300	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized	form lyophilized powder

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Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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