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Monoclonal Anti-Human IgG (Fab specific) antibody produced in mouse

Name: Monoclonal Anti-Human IgG (Fab specific) antibody produced in mouse
Brand: SIGMA
Price: 263 USD
Availability: InStock

clone GG-6, ascites fluid

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$263.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD00162431

Conjugate:

unconjugated

Clone:

GG-6, monoclonal

Application:

ELISA (i)

Citations:

$263.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

GG-6, monoclonal

contains

15 mM sodium azide

technique(s)

indirect ELISA: 1:20,000

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Description

General description

Human IgGs are glycoprotein antibodies that contain two equivalent light chains and a pair of identical heavy chains. IgGs have four distinct isoforms, ranging from IgG1 to IgG4. Monoclonal Anti-Human IgG (Fab specific) antibody is specific for the Fab fragment of human IgG. The antibody does not react with the Fc portion of human IgG.

Monoclonal Anti-Human IgG (Fab Specific) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulin G (IgG) is found in the blood. It is present in the human serum, secreted by the B cells. IgG has the lengthiest serum half-life compared to other immunoglobulins. Heavy and light chains of IgG are interconnected by disulfide bonds.

Immunogen

Purified human IgG

Application

Monoclonal Anti-Human IgG (Fab specific) antibody produced in mouse has been used in enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Maternal IgG passes through the placenta to the fetus and confers immune defense of the neonate against infections. IgG is implicated in antibody-dependent cell-mediated cytotoxicity (ADCC) and also nullifies virus particles and toxins. Papain digestion of IgG generates fragment antigen-binding (Fab). Pepsin digestion of IgG produces fragment crystallizable (fc) fragment and a single dimeric F(ab)².

Monoclonal Anti-Human IgG (Fab Specific) is immunospecific for human IgG. The antibody reacts with the Fab fragment of IgG.

These antibodies regulate immunological responses to allergy and pathogenic infections. IgGs have also been implicated in complement fixation and autoimmune disorders.

Physical form

The product is provided as ascites fluid with 0.1% sodium azide (see MSDS) as a preservative.

Preparation Note

For continuous use, store at 0-5 °C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M4155	SAB4200791	I9010
Sigma-Aldrich I6135 Monoclonal Anti-Human IgG (Fab specific) antibody produced in mouse	Sigma-Aldrich M4155 Anti-Mouse IgG (Fab specific) antibody produced in goat	Sigma-Aldrich SAB4200791 Anti-Human IgG (Fab specific)-Peroxidase antibody, Mouse monoclonal	Sigma-Aldrich I9010 Anti-Human IgG (Fab specific) antibody produced in goat
description clone GG-6, ascites fluid	description 2.0 mg/mL, affinity isolated antibody	description clone GG-6, purified from hybridoma cell culture	description whole antiserum
biological source mouse	biological source goat	biological source mouse	biological source goat
conjugate unconjugated	conjugate unconjugated	conjugate peroxidase conjugate	conjugate unconjugated
antibody form ascites fluid	antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture	antibody form whole antiserum
clone GG-6, monoclonal	clone polyclonal	clone GG-6, monoclonal	clone polyclonal
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
technique(s) indirect ELISA: 1:20,000	technique(s) indirect ELISA: 1:15,000, Ouchterlony double diffusion: suitable	technique(s) direct ELISA: 1:16,000-1:32,000 using 2.5 μg/ml human IgG for coating.	technique(s) quantitative precipitin assay: 4.0 mg/mL, indirect ELISA: 1:30,000

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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