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I9032

Interferon β from mouse

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Synonym(s):

IFN β

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1 vial
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$848.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD02189136

$848.00

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biological source

mouse

Quality Segment

200

recombinant

expressed in E. coli

assay

≥95%

form

buffered aqueous solution

mol wt

~20 kDa

packaging

pkg of 1 vial

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01575

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Ifnb1(15977)

General description

Interferon β (IFN-β) possesses a signal peptide region. It has comparatively more hydrophobic residues and displays 30% homology with IFN-α.
The gene encoding interferon β (Infb1) is localized on mouse chromosome 4.
IFN β (interferon β) is from the type 1 interferon family of cytokines.

Application

Interferon β from mouse has been used:
  • to induce the activation of cholesterol 25-hydroxylase, by in vitro stimulation of bone marrow-derived macrophages, dendritic cells and CD11c+ lung macrophages
  • to stimulate splenocytes, in order to study the secretion and regulation of IFN-γ
  • to intranasally pre-treat neonatal mice, to study its effects on the protective actions of Lactobacillus rhamnosus GG (LGG)
  • as a standard to treat MEF-Mx2-luc-BKO reporter cell line for IFN-β measurement, in response to human adenovirus-5 (HAdV-C5)
Interferon β from mouse has been used:
  • in the stimulation of bone marrow-derived dendritic cells (BMDCs)
  • as a cytokine to stimulate differentiation of podocytes
  • to stimulate splenocytes

Biochem/physiol Actions

Interferon β has a role in the activation of human leukocyte antigen (HLA) gene expression. It acts as a messenger during bacterial infections.
In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response. It is also important for anti-inflammatory effects.
Interferon β (IFN-β) suppresses a variety of proinflammatory cytokines in lymphocytes including the interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α). It also favors the synthesis of antagonists associated with interleukin IL-10 and IL-1 receptor. IFN-β downregulates interferon γ production but enhances transforming growth factor β1 expression. It has therapeutic potential in treating rheumatoid arthritis and relapsing-remitting multiple sclerosis (MS).
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Physical form

Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.

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Interferon β from mouse ≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

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Sigma-Aldrich

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description

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

description

Interferon-α A Protein, Recombinant mouse.

description

IFN-gamma, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested

description

≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

assay

≥95%

assay

>95%

assay

≥98% (SDS-PAGE)

assay

≥95%

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in CHO cells

biological source

mouse

biological source

mouse

biological source

-

biological source

rat

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

200

form

buffered aqueous solution

form

liquid

form

lyophilized powder

form

lyophilized powder

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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