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I9032

Interferon β from mouse

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Synonym(s):

IFN β

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1 vial
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9 760,00 kr

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD02189136

9 760,00 kr

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biological source

mouse

Quality Segment

200

recombinant

expressed in E. coli

assay

≥95%

form

buffered aqueous solution

mol wt

~20 kDa

packaging

pkg of 1 vial

concentration

2560000 units/mL

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01575

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Ifnb1(15977)

General description

Interferon β (IFN-β) possesses a signal peptide region. It has comparatively more hydrophobic residues and displays 30% homology with IFN-α.
The gene encoding interferon β (Infb1) is localized on mouse chromosome 4.PMID 7683574
IFN β (interferon β) is from the type 1 interferon family of cytokines.[1]

Application

Interferon β from mouse has been used:
  • in the stimulation of bone marrow-derived dendritic cells (BMDCs)[2]
  • as a cytokine to stimulate differentiation of podocytes[3]
  • to stimulate splenocytes

Interferon β from mouse has been used:
  • to induce the activation of cholesterol 25-hydroxylase, by in vitro stimulation of bone marrow-derived macrophages, dendritic cells and CD11c+ lung macrophages[2]
  • to stimulate splenocytes, in order to study the secretion and regulation of IFN-γ [4]
  • to intranasally pre-treat neonatal mice, to study its effects on the protective actions of Lactobacillus rhamnosus GG (LGG)[5]
  • as a standard to treat MEF-Mx2-luc-BKO reporter cell line for IFN-β measurement, in response to human adenovirus-5 (HAdV-C5)[6]

Biochem/physiol Actions

Interferon β has a role in the activation of human leukocyte antigen (HLA) gene expression.PMID 9301532 It acts as a messenger during bacterial infections.PMID 28422568
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response.[7] It is also important for anti-inflammatory effects.[1]
Interferon β (IFN-β) suppresses a variety of proinflammatory cytokines in lymphocytes including the interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α).[8] It also favors the synthesis of antagonists associated with interleukin IL-10 and IL-1 receptor.[8] IFN-β downregulates interferon γ production but enhances transforming growth factor β1 expression.[8] It has therapeutic potential in treating rheumatoid arthritis[8] and relapsing-remitting multiple sclerosis (MS).[9]

Physical form

Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.

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description

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

description

≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

description

≥95%, recombinant, expressed in bacteria, lyophilized powder, suitable for cell culture

description

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

assay

≥95%

assay

≥95%

assay

≥95%

assay

≥98% (SDS-PAGE)

recombinant

expressed in E. coli

recombinant

expressed in CHO cells

recombinant

expressed in bacteria

recombinant

expressed in E. coli

biological source

mouse

biological source

rat

biological source

rat

biological source

mouse

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

buffered aqueous solution

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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