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IL-6 mouse

Name: IL-6 mouse
Brand: SIGMA
Price: 445 USD
Availability: InStock

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-6, mIL-6, IL-6

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Size/SKU	Availability	Price
5 μg	Check Cart for Availability	$445.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD01656039

Biological source:

mouse

Recombinant:

expressed in E. coli

Assay:

≥97% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

~21.7 kDa

Impurities:

≤1.000 EU/mg Endotoxin level

$445.00

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Properties

Product Name

Interleukin-6 from mouse, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free

biological source

mouse

Quality Segment

200

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

0.02-0.2 ng/mL EC₅₀

quality

endotoxin tested

mol wt

~21.7 kDa

packaging

pkg of 5 and 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1.000 EU/mg Endotoxin level

color

white

UniProt accession no.

P08505

storage temp.

−20°C

Description

General description

Recombinant mouse Interleukin‑6 (IL‑6) is a multifunctional cytokine expressed in E. coli and supplied as a carrier‑free lyophilized powder. IL‑6 is widely used in mammalian cell culture research involving immune and inflammatory signaling pathways in vitro.

Application

Recombinant mouse IL‑6 has been used in mammalian cell culture research applications, including immune cell proliferation assays and cytokine‑mediated signaling studies in vitro.

Biochem/physiol Actions

Interleukin‑6 (IL‑6) is an immunomodulatory cytokine that supports proliferation and differentiation of multiple cell types. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 is involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response.

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β₂), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Physical form

Lyophilized from a sterile filtered solution with no additives.

Analysis Note

The biological activity of recombinant mouse IL-6 was measured in a cell proliferation assay using T1165.85.2.1 cells.

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Show Differences

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This Item	I1145	I3019	I0406
Sigma-Aldrich I9646 Interleukin-6 from mouse	Sigma-Aldrich I1145 Interleukin-5 from mouse	Sigma-Aldrich I3019 Interleukin-10 from mouse	Sigma-Aldrich I0406 Interleukin-6 from rat
description IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free	description ≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture	description >97% (SDS-PAGE), recombinant, expressed in E. coli, suitable for cell culture	description IL-6, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay >97% (SDS-PAGE)	assay >97% (SDS-PAGE)
recombinant expressed in E. coli	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in E. coli	recombinant expressed in E. coli
biological source mouse	biological source mouse	biological source mouse	biological source rat
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form buffered aqueous solution

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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