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K4013

Kasugamycin hydrochloride from Streptomyces kasugaensis

Synonym(s):

3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol

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Size/SKUAvailabilityPrice
10 g

Available to ship TODAYfromMILWAUKEE

$466.00

About This Item

Empirical Formula (Hill Notation):
C14H25N3O9 · HCl
CAS Number:
Molecular Weight:
415.82
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:

$466.00


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biological source

Streptomyces kasugaensis

Quality Segment

form

powder

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](N)C[C@@H]1NC(C(O)=O)=N.Cl

InChI

1S/C14H25N3O9.ClH/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22;/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24);1H/t3-,4+,5+,6-,7+,8+,9-,10+,11+,14-;/m1./s1

InChI key

ZDRBJJNXJOSCLR-NZXABURVSA-N

General description

Chemical structure: aminoglycoside

Application

Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near the m26A m26A sequence. It is used to study the mechanisms of kasugamycin resistance.

Biochem/physiol Actions

Kasugamycin binds within the mRNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA. It inhibits protein synthesis and binding of aminoacyl-sRNA to the ribosomes in fungi and induces f-met-tRNA dissociation from the P-site of the 30S subunit.

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This Item
32354K4000K1876
description

-

description

VETRANAL®, analytical standard

description

Animal Component-free

description

aminoglycoside antibiotic

antibiotic activity spectrum

Gram-positive bacteria, Gram-negative bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

Gram-positive bacteria, mycoplasma, mycobacteria, Gram-negative bacteria

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma

mode of action

protein synthesis | interferes

mode of action

-

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

200

form

powder

form

-

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

biological source

Streptomyces kasugaensis

biological source

-

biological source

Streptomyces kanamyceticus

biological source

Streptomyces kanamyceticus


Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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