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L2011

D-Lactic Dehydrogenase from Lactobacillus leichmannii

ammonium sulfate suspension, ≥250 units/mg protein (biuret)

Synonym(s):

Lactate, (R)-Lactate:NAD+ oxidoreductase, D−LDH

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2500 units
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$706.00
5000 units
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$1,260.00

About This Item

CAS Number:
9028-36-8
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
1.1.1.28 (BRENDA, IUBMB)
MDL number:
MFCD00130907
Specific activity:
≥250 units/mg protein (biuret)

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form

ammonium sulfate suspension

Quality Level

200

specific activity

≥250 units/mg protein (biuret)

foreign activity

Malic dehydrogenase <0.5% of base activity

storage temp.

2-8°C

General description

Research area: Cell Signalling D-lactate dehydrogenase belongs to the D-isomer-specific 2-hydroxyacid dehydrogenase family.[1] Lactate dehydrogenase (LD) is a tetramer consisting of two (H and M) subunits. It has five isozymes (LD1 to LD5) and this composition varies in different tissues. LD1 is abundant in the kidney, heart, and erythrocytes. LD5 is found in the liver and skeletal muscles.[2] LD is a ubiquitous molecule found in plants, yeast, mammals, and microorganisms and is a member of the oxidoreductase family.[3]

Biochem/physiol Actions

Lactic dehydrogenase (LDH)plays an important role in the glycolytic pathway where it converts pyruvate tolactate by using NAD+ as a co-factor. It is considered animportant molecule that can be used in cancer therapy as it acts as aglycolytic inhibitor. Inhibition of LDH is associated with blocking of aerobicglycolysis in tumour cells.[2]

Physical form

Suspension in 3.2 M (NH4)2SO4, pH 6.0

Other Notes

One unit will reduce 1.0 μmole of pyruvate to D-lactate per min at pH 7.0 at 25 °C.

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L-Lactic Dehydrogenase from bovine heart Type III, ammonium sulfate suspension, &#8805;500&#160;units/mg protein

Sigma-Aldrich

L2625

L-Lactic Dehydrogenase from bovine heart

specific activity

≥250 units/mg protein (biuret)

specific activity

150-500 units/mg protein

specific activity

≥60 units/mg protein

specific activity

≥500 units/mg protein

form

ammonium sulfate suspension

form

lyophilized powder

form

lyophilized powder

form

ammonium sulfate suspension

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

foreign activity

Malic dehydrogenase <0.5% of base activity

foreign activity

Malic dehydrogenase <0.5% of base activity

foreign activity

-

foreign activity

pyruvate kinase ≤0.03%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000213715
0000384463
0000384463
0000213715
0000424170

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Articles

How to Work with Enzymes Supplied as Ammonium Sulfate Suspensions

Instructions for working with enzymes supplied as ammonium sulfate suspensions

Related Content

H Taguchi et al.
The Journal of biological chemistry, 266(19), 12588-12594 (1991-07-05)
The gene encoding D-lactate dehydrogenase (D-lactate: NAD+ oxidoreductase, EC 1.1.1.28) of Lactobacillus plantarum has been sequenced, and expressed in Escherichia coli cells with an inducible expression plasmid, in which the 5'-noncoding region of the gene was replaced with the tac
Torben Larsen
Analytical biochemistry, 539, 152-157 (2017-11-06)
D-lactic acid in the mammalian body is mainly of microbiological origin and is often located somewhere along the digestive tract. Surgical, extensive re-sectioning of the small bowel may be one of the risk factors for altered balance in the microbiological
D L Zhang et al.
Postgraduate medical journal, 79(928), 110-112 (2003-03-04)
A 12 year old boy presented with 11 episodes of weakness, ataxia, nausea, slurred speech, dehydration, and sometimes severe lethargy bordering on coma. A year previously the boy had small intestinal resections leaving 20 cm of small bowel remaining. D-lactic
View All Related Papers

Global Trade Item Number

SKUGTIN
L2011-5KU04061833949719
L2011-2.5KU04061838173126

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