The concentration of this solution varies from lot to lot and is reported in the lot specific Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/l2913#product-documentation
Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/358/996/l2913dat.pdf
L2913
Leptomycin B
from Streptomyces sp., ≥95% (HPLC), solution, nuclear transport inhibitor
Synonym(s):
Antibiotic CI 940, Elactocin, LMB, Mantuamycin
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| Size/SKU | Availability | Price |
|---|---|---|
0.5 μg | Please contact Customer Service for Availability | $86.00 |
2 x 0.5 μg | Please contact Customer Service for Availability | $161.00 |
5 x 0.5 μg | Please contact Customer Service for Availability | $340.00 |
5 μg | Please contact Customer Service for Availability | $546.00 |
10 x 0.5 μg | Please contact Customer Service for Availability | $549.00 |
About This Item
Empirical Formula (Hill Notation):
C33H48O6
CAS Number:
Molecular Weight:
540.73
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Storage condition:
protect from light
Product Name
Leptomycin B solution from Streptomyces sp., ≥95% (HPLC), Supplied in methanol: water (7:3)
Quality Segment
assay
≥95% (HPLC)
storage condition
protect from light
antibiotic activity spectrum
fungi
mode of action
protein synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
InChI
1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
InChI key
YACHGFWEQXFSBS-XYERBDPFSA-N
General description
Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.
Biochem/physiol Actions
Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
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This Item | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay >85% (HPLC) | assay - | assay - |
| Quality Level 300 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition protect from light | storage condition OK to freeze | storage condition - | storage condition - |
| shipped in dry ice | shipped in ambient | shipped in - | shipped in - |
| antibiotic activity spectrum fungi | antibiotic activity spectrum - | antibiotic activity spectrum fungi | antibiotic activity spectrum fungi |
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
64.4 °F - closed cup
flash_point_c
18 °C - closed cup
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