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M3795

IgM, Kappa from murine myeloma

clone TEPC 183, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Mouse IgM-κ

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1 mg

Available to ship TODAYfromMILWAUKEE

$339.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.46
MDL number:
MFCD00283897
Conjugate:
unconjugated
Clone:
TEPC 183, monoclonal
Application:
—
Citations:
22

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biological source

mouse

Quality Segment

300

conjugate

unconjugated

antibody form

purified immunoglobulin

clone

TEPC 183, monoclonal

assay

≥90% (HPLC)

form

buffered aqueous solution

concentration

2.0-2.2 mg/mL

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

IgM is a highly conserved antibody in vertebrates and is expressed early during immune response. It is secreted by peritoneal B cells.
IgM antibodies are present as pentamers in the serum and are produced in response to antigens IgM, κ from murine myeloma is produced by TEPC 183 tumor line introduced subcutaneously in BALB/c mice.
Determined by the absorbance at 280 nm (E1%/280 = 11.8). Each vial contains at least 1 mg of purified myeloma protein.

Application

IgM, Kappa from murine myeloma has been used in:
  • sandwich enzyme linked immunosorbent assay (ELISA)
  • flow cytometry
  • dot-immunobinding assay

Biochem/physiol Actions

IgM plays a key role in the engulfing of apoptotic cells. A reduction in serum IgM levels leads to increased autoimmune response and higher risk for infections. IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating clearance of tissue based molecules. IgM has sites for N-linked glycosylation, with sugars namely, mannose, galactose, N-acetyl glucosamine and sialic acid. IgM linked agarose resins have been tested for efficient conjugate binding.
The TEPC 183 tumor line is pristine-induced plasmacytoma-originated and carried subcutaneously in BALB/c mice. The hapten binding specificity of the TEPC 183 line has not been determined. It specifically recognizes mouse IgM. Identity and purity of the immunoglobulin is established by immunoelectrophoresis.

Physical form

Solution in 0.05 M Tris, 0.5 M sodium chloride, pH 8.0, containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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description

clone TEPC 183, purified immunoglobulin, buffered aqueous solution

description

clone MOPC 31C, purified immunoglobulin, buffered aqueous solution

description

clone MOPC 31C, ascites fluid, lyophilized powder

description

clone MOPC 21, ascites fluid, lyophilized powder

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

clone

TEPC 183, monoclonal

clone

MOPC 31C, monoclonal

clone

MOPC 31C, monoclonal

clone

MOPC 21, monoclonal

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

ascites fluid

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

-

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

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Storage Class

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flash_point_f

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flash_point_c

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