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Platelet-Derived Growth Factor-AA human

Name: Platelet-Derived Growth Factor-AA human
Brand: SIGMA
Price: 482 USD
Availability: InStock

PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

PDGF−AA

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Size/SKU	Availability	Price
10 μg	Available to ship TODAYfromMILWAUKEE	$482.00
50 μg	Available to ship TODAYfromMILWAUKEE	$992.00 $843.20

About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00081862

Biological source:

human

Recombinant:

expressed in E. coli

Assay:

≥98% (SDS-PAGE and HPLC)

Form:

lyophilized powder

Mol wt:

28.5 kDa (containing 250 amino acid residues)

Impurities:

<1 EU/μg

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Properties

biological source

human

Quality Segment

100

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

≤1.0-3.0 ng/mL ED₅₀

quality

endotoxin tested

mol wt

28.5 kDa (containing 250 amino acid residues)

packaging

pkg of 10 μg, pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg

UniProt accession no.

P04085

storage temp.

−20°C

Gene Information

human ... PDGFRA(5154)

Description

General description

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

Biochem/physiol Actions

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

Physical form

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

Other Notes

Homodimer of the A chain of human PDGF.

Compare Similar Items

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Show Differences

1 of 1

This Item	P3201	P3326	P4056
Sigma-Aldrich P3076 Platelet-Derived Growth Factor-AA human	Sigma-Aldrich P3201 Platelet-Derived Growth Factor-BB human	Sigma-Aldrich P3326 Platelet-Derived Growth Factor-AB human	Sigma-Aldrich P4056 Platelet-Derived Growth Factor-BB from rat
description PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description PDGF-AB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay ≥98% (SDS-PAGE and HPLC)	assay ≥98% (HPLC and SDS-PAGE)	assay ≥97% (SDS-PAGE and N-terminal analysis)	assay ≥97% (SDS-PAGE)
biological source human	biological source human	biological source human	biological source rat
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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