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R3375

Retinyl palmitate

Type IV, ~1,800,000 USP units/g, oil

Synonym(s):

Vitamin A palmitate, all−trans−Retinol palmitate

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Size/SKUAvailabilityPrice
1 g
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$91.10
$77.43
5 g
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$367.00
$275.25

About This Item

Empirical Formula (Hill Notation):
C36H60O2
CAS Number:
79-81-2
Molecular Weight:
524.86
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
24899361
EC Number:
201-228-5
Beilstein/REAXYS Number:
1917366
MDL number:
MFCD00019414

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biological source

synthetic (organic)

Quality Segment

100

type

Type IV

assay

≥90% (HPLC)

form

oil

specific activity

~1,800,000 USP units/g

color

yellow to orange

mp

26 °C

storage temp.

2-8°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1

InChI

1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+

InChI key

VYGQUTWHTHXGQB-FFHKNEKCSA-N

General description

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A, respectively. The retinoids comprise a cyclohexenyl ring with a 20-carbon with double bonds in cis and trans configuration. Retinyl palmitate is a major storage form of vitamin A. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Application

Retinyl palmitate has been used as:
  • a retinoid derivative to modulate expression of connexin Cx26 and Cx30 in the cochlea
  • a standard in high performance liquid chromatography(HPLC)
  • as a retinoid substrate in the isomerase assay of eyecup protein homogenates

Biochem/physiol Actions

Review: Vitamin A metabolism.
Retinoids are ligands to nuclear receptors and have antioxidant functionality. Retinyl palmitate is widely used in pharmaceutical and cosmetic applications. In sunscreen, it protects from UVB-induced DNA damage and apoptosis. Retinyl palmitate is used to treat photoaging in skincare cosmetics. Retinyl palmitate is an effective chemopreventive agent to treat lung cancer. It also regulates various biological processes including cell differentiation and proliferation.

Packaging

Sealed ampule.

Physical form

Oil at room temperature

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This Item
PHR1235R151287809
Retinyl palmitate Type IV, ~1,800,000 USP units/g, oil

Sigma-Aldrich

R3375

Retinyl palmitate

Retinyl Palmitate (Vitamin A Palmitate) Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1235

Retinyl Palmitate (Vitamin A Palmitate)

Retinyl palmitate potency: ≥1,700,000 USP units per g

Sigma-Aldrich

R1512

Retinyl palmitate

Retinyl propionate ≥98.0% (sum of isomers, HPLC), ~2500 U/mg

Sigma-Aldrich

87809

Retinyl propionate

description

Type IV, ~1,800,000 USP units/g, oil

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

potency: ≥1,700,000 USP units per g

description

≥98.0% (sum of isomers, HPLC), ~2500 U/mg

assay

≥90% (HPLC)

assay

-

assay

-

assay

≥98.0% (sum of isomers, HPLC)

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

synthetic

form

oil

form

-

form

solid or viscous liquid

form

liquid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

color

yellow to orange

color

-

color

yellow to yellow-green

color

green-yellow to very dark green-yellow, yellow to very dark yellow

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

100

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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