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S101

(R)-(+)-SKF-38393 hydrochloride

≥98% (HPLC), solid

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5 mg

Available to ship TODAYfromMILWAUKEE

$296.00

About This Item

Empirical Formula (Hill Notation):
C16H17NO2 · HCl
CAS Number:
81702-42-3
Molecular Weight:
291.77
NACRES:
NA.77
PubChem Substance ID:
329824192
UNSPSC Code:
12352200
MDL number:
MFCD00055189
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D +16.1°, c = 1.2 in methanol(lit.)

storage condition

desiccated

color

off-white to light tan

solubility

0.1 M HCl: 1.2 mg/mL, ethanol: 3.4 mg/mL, H2O: 5 mg/mL, aqueous base: unstable

SMILES string

Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O

InChI

1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1

InChI key

YEWHJCLOUYPAOH-PFEQFJNWSA-N

Application

(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).[1]

Biochem/physiol Actions

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist [1] and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons.[2] SKF-38393, a benzazepine derivative,[3] exhibits anorectic effects.[4]

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Solutions may be stored for several days at 4 °C.

Disclaimer

Light sensitive

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This Item
D047D054L131
(R)-(+)-SKF-38393 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

S101

(R)-(+)-SKF-38393 hydrochloride

(±)-SKF-38393 hydrochloride crystalline, ≥98% (HPLC)

Sigma-Aldrich

D047

(±)-SKF-38393 hydrochloride

R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

D054

R(+)-SCH-23390 hydrochloride

L-745,870 hydrochloride

Sigma-Aldrich

L131

L-745,870 hydrochloride

form

solid

form

crystalline

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage condition

desiccated

storage condition

desiccated, protect from light

storage condition

desiccated, protect from light

storage condition

-

solubility

0.1 M HCl: 1.2 mg/mL, H2O: 5 mg/mL, aqueous base: unstable, ethanol: 3.4 mg/mL

solubility

H2O: >5 mg/mL, aqueous base: soluble (unstable)

solubility

H2O: >5 mg/mL

solubility

H2O: 0.2 mg/mL, ethanol: 1.4 mg/mL, 0.1 M HCl: 5.5 mg/mL

color

off-white to light tan

color

white

color

white

color

white

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000534132
0000534132
0000283664
0000283664
020M4602V

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M R Zarrindast et al.
Pharmacology, 87(1-2), 85-89 (2011-01-19)
Both the dopamine receptor D(1) agonist SKF 38393 and the antagonist SCH 23390 are benzazepine derivatives that have been widely used as pharmacological tools and radioligands. Evidence suggests that behavioral effects of both compounds do not always correspond to their
Carole Hyacinthe et al.
Neurobiology of disease, 63, 20-24 (2013-11-12)
Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
A Bouron et al.
Neuroscience, 94(4), 1063-1070 (2000-01-07)
The present study was undertaken to better assess the role of dopamine on exocytosis. Since direct activation of adenylate cyclase (e.g., with forskolin) enhances neurotransmitter release it was of interest to see whether the activation of D1-type dopamine receptors, which
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Global Trade Item Number

SKUGTIN
S101-5MG04061836831349
S101-100MG04061832093284

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