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S1437

Sex Hormone-Binding Globulin from human serum

≥95% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

SHBG, Testosterone-estradiol binding globulin

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10 μg
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$795.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00163748
Form:
buffered aqueous glycerol solution
Assay:
≥95% (SDS-PAGE)
Biological source:
human serum

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biological source

human serum

Quality Segment

assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SHBG(6462)

General description

Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.

Application

Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.

Biochem/physiol Actions

Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.

Physical form

Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4

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RAB0734WH0006462M1345802
Sex Hormone-Binding Globulin from human serum ≥95% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

S1437

Sex Hormone-Binding Globulin from human serum

Human SHBG / Sex Hormone-binding Globulin ELISA Kit

Sigma-Aldrich

RAB0734

Human SHBG / Sex Hormone-binding Globulin ELISA Kit

Monoclonal Anti-SHBG antibody produced in mouse clone 5E6, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

WH0006462M1

Monoclonal Anti-SHBG antibody produced in mouse

Gc-Globulin, Mixed Type, Human Plasma Native Gc-globulin from human plasma. Single polypeptide chain present in plasma at about 20-55 mg/dl. Functions in binding and transport of vitamin D.

Sigma-Aldrich

345802

Gc-Globulin, Mixed Type, Human Plasma

description

≥95% (SDS-PAGE), buffered aqueous glycerol solution

description

-

description

clone 5E6, purified immunoglobulin, buffered aqueous solution

description

Native Gc-globulin from human plasma. Single polypeptide chain present in plasma at about 20-55 mg/dl. Functions in binding and transport of vitamin D.

assay

≥95% (SDS-PAGE)

assay

-

assay

-

assay

≥95% (SDS-PAGE)

technique(s)

cell culture | mammalian: suitable

technique(s)

ELISA: suitable

technique(s)

western blot: 1-5 μg/mL, indirect ELISA: suitable

technique(s)

-

biological source

human serum

biological source

-

biological source

mouse

biological source

human plasma

form

buffered aqueous glycerol solution

form

-

form

buffered aqueous solution

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P04278

UniProt accession no.

-

UniProt accession no.

P04278

UniProt accession no.

-

Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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