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S1437

Sex Hormone-Binding Globulin from human serum

≥95% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

SHBG, Testosterone-estradiol binding globulin

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Size/SKUAvailabilityPrice
10 μg
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$767.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Form:
buffered aqueous glycerol solution
Assay:
≥95% (SDS-PAGE)
Biological source:
human serum

$767.00


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biological source

human serum

Quality Segment

assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SHBG(6462)

General description

Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.

Application

Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.

Biochem/physiol Actions

Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.

Physical form

Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4

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I5403SRP3067R9388
description

≥95% (SDS-PAGE), buffered aqueous glycerol solution

description

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

description

buffered aqueous solution

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

transfection: suitable, cell culture | embryo: suitable

biological source

human serum

biological source

human

biological source

human

biological source

human urine

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥85% (SDS-GE)

form

buffered aqueous glycerol solution

form

lyophilized powder

form

lyophilized

form

buffered aqueous solution

shipped in

dry ice

shipped in

-

shipped in

wet ice

shipped in

dry ice

UniProt accession no.

P04278

UniProt accession no.

P18065

UniProt accession no.

P17936

UniProt accession no.

P09455


Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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