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S1688

SR 57227A

solid

Synonym(s):

4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride

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Size/SKUAvailabilityPrice
5 mg
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$236.00

About This Item

Empirical Formula (Hill Notation):
C10H14ClN3 · HCl
CAS Number:
Molecular Weight:
248.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid

$236.00


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form

solid

Quality Segment

color

white

solubility

H2O: soluble 9 mg/mL

SMILES string

Cl.NC1CCN(CC1)c2cccc(Cl)n2

InChI

1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H

InChI key

FUMINTAAUJUVMP-UHFFFAOYSA-N

Application

SR 57227A may be used in 5-HT3-mediated cell signaling studies.

Biochem/physiol Actions

SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
Potent and selective 5-HT3 serotonin receptor agonist.

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This Item
M0763T3146M1514
description

solid

description

solid

description

≥98% (TLC), powder

description

≥90% (HPLC)

form

solid

form

solid

form

powder

form

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

solubility

H2O: soluble 9 mg/mL

solubility

H2O: soluble

solubility

chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow

solubility

-

color

white

color

white

color

white to off-white

color

-

Gene Information

human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

Gene Information

human ... DRD2(1813), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360)

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)


Signal Word

Danger

Pictograms

Skull and crossbones

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges



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