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S9396

Sphingomyelinase from Bacillus cereus

buffered aqueous glycerol solution, ≥100 units/mg protein (Lowry)

Synonym(s):

Sphingomyelin choline phosphohydrolase, Sphingomyelin phosphodiesterase

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Size/SKUAvailabilityPrice
25 units
Please contact Customer Service for Availability
₹22,077.90
50 units
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₹40,082.10

About This Item

CAS Number:
9031-54-3
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
3.1.4.12 (BRENDA, IUBMB)
MDL number:
MFCD00132362
Specific activity:
≥100 units/mg protein (Lowry)

₹22,077.90

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Quality Segment

200

form

buffered aqueous glycerol solution

specific activity

≥100 units/mg protein (Lowry)

mol wt

34.2 kDa

foreign activity

Phospholipase C ≤1%

storage temp.

2-8°C

Gene Information

Bacillus cereus ATCC 10987 ... spH(2751530)

General description

Sphingomyelinase (SMase) is a hydrolase, of 34.2 kDa and its active site contain as a minimum of two magnesium atoms.

Application

Sphingomyelinase from Bacillus cereus has been used:
  • in the study to analyse the effect of sphingomyelinase on Rubella virus infectivity in cell lines
  • in lipoprotein modification for the generation of cholesterol crystals in vitro
  • to aggregate LDL (low-density lipoprotein)

Sphingomyelinase has been used in a study to assess the interaction of actin with the HIV-1 accessory protein Nef. [1] Sphingomyelinase has also been used in a study to investigate X-ray scattering as a quality-control tool for liposomal drug-delivery systems. [2]

Biochem/physiol Actions

Sphingomyelin phosphodiesterase (SMPD) participates in the metabolic reactions comprising sphingomyelin. SMPD has the ability to prevent colorectal carcinoma and colitis.
Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.

Physical form

Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5.

Other Notes

One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.

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Sphingomyelinase from Bacillus cereus buffered aqueous glycerol solution, ≥100 units/mg protein (Lowry)

Sigma-Aldrich

S9396

Sphingomyelinase from Bacillus cereus

Sphingomyelinase from Staphylococcus aureus buffered aqueous glycerol solution, 100-300 units/mg protein (Lowry)

Sigma-Aldrich

S8633

Sphingomyelinase from Staphylococcus aureus

Sphingomyelinase from Bacillus cereus lyophilized powder, ≥100 units/mg protein

Sigma-Aldrich

S7651

Sphingomyelinase from Bacillus cereus

Sphingomyelinase, Staphylococcus aureus

Sigma-Aldrich

567707

Sphingomyelinase, Staphylococcus aureus

specific activity

≥100 units/mg protein (Lowry)

specific activity

100-300 units/mg protein (Lowry)

specific activity

≥100 units/mg protein

specific activity

≥100 units/mg protein

Gene Information

Bacillus cereus ATCC 10987 ... spH(2751530)

Gene Information

-

Gene Information

Bacillus cereus ATCC 14579 ... BC0671(1203022)

Gene Information

-

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

lyophilized powder

form

liquid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mol wt

34.2 kDa

mol wt

-

mol wt

36873 Da

mol wt

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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