Unfortunately, the stability information of this product in DMSO is not determined.
SML2652
Peretinoin
≥97% (HPLC)
Synonym(s):
K333, NIK 333, 3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, (2E,4E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,4,6,10,14-pentaenoic acid, 4,5-Didehydrogeranyl geranoic acid, ACR, Acyclic retinoid, E 5166, E-5166, E5166, K 333, K-333, NIK-333, NIK333, Polyprenoic acid, all-trans-3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Available to ship TODAYfromMILWAUKEE | $107.00 $90.95 |
25 mg | Check Cart for Availability | $348.00 |
About This Item
Empirical Formula (Hill Notation):
C20H30O2
CAS Number:
Molecular Weight:
302.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
$90.95
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Available to ship TODAYDetails
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(=O)\C=C(/C)\C=C\C=C(\CC\C=C(\CCC=C(C)C)/C)/C
InChI
1S/C20H30O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h8-9,11,13-15H,6-7,10,12H2,1-5H3,(H,21,22)/b14-8+,17-11+,18-13+,19-15+
InChI key
UUBHZHZSIKRVIV-KCXSXWJSSA-N
Biochem/physiol Actions
Peretinoin is an orally active synthetic acyclic retinoid (ACR) whose in vivo anti-hepatocellular carcinoma (HCC) efficacy is attributed to its upregulatory activity toward retinoid nuclear receptors (RARbeta & RXRalpha), as well as negative regulation against sphingosine kinase 1 (SPHK1) expression and, thereby, sphingosine metabolic pathway. Peretinoin inhibits the replication of hepatitis B & C viruses in cultures (HBV & HCV EC50 = 9-25 μM) and shows in vivo efficacy in rodent models of hepatocarcinogenesis among rats (10, 40, or 80 mg/kg/day p.o.) and mice (0.03% or 0.06% in diet) subjected to chronic inflammation induction by diethylnitrosamine (DEN).
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This Item | |||
|---|---|---|---|
| description ≥97% (HPLC) | description ≥98% (HPLC), powder | description ≥98% (HPLC) | description European Pharmacopoeia (EP) Reference Standard |
| form powder | form powder | form powder | form solid |
| assay ≥97% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −70°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility chloroform: 50 mg/mL | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color yellow | color faint brown to dark brown, deep red-brown | color - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Wie lang ist das Peretinoin haltbar/ verwendbar nach anmischen mit DMSO?
1 answer-
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