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NT-3 human

Name: NT-3 human
Brand: SIGMA
Price: 235 USD
Availability: InStock

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

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Synonym(s):

HGNF, NGF-2, Nerve growth factor-2, Neurotrophic factor, Neurotrophin-3

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10 μg	Usually ships in 2 weeks.	$235.00

About This Item

NACRES:

NA.32

UNSPSC Code:

12352202

$235.00

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Properties

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

potency

≤20 ng/mL ED₅₀/EC₅₀

mol wt

13.6 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

P20783

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NTF3(4908)

Description

General description

NT-3 (neurotrophin 3) is a neurotrophic factor structurally related to β-NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6kDa polypeptide monomers (240 total amino acid residues). The amino acid sequences of human, murine and rat NT-3 are identical.

Biochem/physiol Actions

NT-3 (neurotrophin 3) promotes the growth and survival of nerve and glial cells. It is associated with neuroprotection and polymorphisms in the gene are associated with risk to Alzheimer′s disease. It is also linked with attention-deficit/hyperactivity disorder (ADHD) and mood disorders. NT-3 enhances the metastatic proliferation of breast cancer cells in the brain.

Physical form

Lyophilized with no additives.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Other Notes

MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

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This Item	N1905	GF308	SRP3018
Sigma-Aldrich SRP3128 NT-3 human	Sigma-Aldrich N1905 Neurotrophin-3 human	Sigma-Aldrich GF308 NT-3 Protein, Human Recombinant Animal Free	Sigma-Aldrich SRP3018 Beta -NGF human
description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)	description Recombinant animal free human NT-3 is manufactured using all non-animal reagents.	description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
assay ≥98% (SDS-PAGE), ≥98% (HPLC)	assay >97% (SDS-PAGE)	assay >98% (SDS-PAGE and HPLC)	assay ≥98% (SDS-PAGE), ≥98% (HPLC)
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| mammalian: suitable
recombinant expressed in E. coli	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in E. coli	recombinant expressed in E. coli
biological source human	biological source human	biological source -	biological source human
form lyophilized	form lyophilized powder	form -	form lyophilized
UniProt accession no. P20783	UniProt accession no. P20783	UniProt accession no. P20783	UniProt accession no. P01138

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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