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Thyroglobulin from bovine thyroid

Name: Thyroglobulin from bovine thyroid
Brand: SIGMA

powder, ≥90% (agarose gel electrophoresis)

Synonym(s):

Globulins thyro, Thyractin

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About This Item

CAS Number:

9010-34-8

UNSPSC Code:

12352202

EC Number:

232-721-3

NACRES:

NA.61

MDL number:

MFCD00132429

Form:

powder

Assay:

≥90% (agarose gel electrophoresis)

Biological source:

bovine thyroid

Mol wt:

~670 kDa

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Properties

biological source

bovine thyroid

Quality Segment

200

assay

≥90% (agarose gel electrophoresis)

form

powder

mol wt

~670 kDa

composition

Iodine, ≥0.20%

nitrogen analysis

13.0-16.0% total

ash

≤4%

solubility

H₂O: 20 mg/mL

UniProt accession no.

P01267

storage temp.

−20°C

Gene Information

cow ... TG(280706)

Description

Application

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.

Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Biochem/physiol Actions

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

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This Item	T9145	609312	T-113
Sigma-Aldrich T1001 Thyroglobulin from bovine thyroid	Sigma-Aldrich T9145 Thyroglobulin from bovine thyroid	Sigma-Aldrich 609312 Thyroglobulin, Human Thyroid	Supelco T-113 Thyroglobulin solution
description powder, ≥90% (agarose gel electrophoresis)	description (For Gel Filtration Chromatography)	description -	description 10 μg/mL (SigMatrix Serum Diluent), certified reference material, ampule of 1 mL, Cerilliant^®
biological source bovine thyroid	biological source bovine thyroid	biological source human thyroid	biological source -
assay ≥90% (agarose gel electrophoresis)	assay -	assay ≥95% (PAGE)	assay -
form powder	form powder	form lyophilized	form liquid
mol wt ~670 kDa	mol wt ~670 kDa	mol wt -	mol wt 302607 Da
solubility H₂O: 20 mg/mL	solubility -	solubility -	solubility -
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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