We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.
T2036
apo-Transferrin human
powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)
Synonym(s):
Human transferrin, Siderophilin
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Available to ship TODAYfromMILWAUKEE | $209.00 |
500 mg | Available to ship TODAYfromMILWAUKEE | $665.00 |
1 g | Available to ship TODAYfromMILWAUKEE | $1,120.00 |
About This Item
CAS Number:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.75
MDL number:
eCl@ss:
34058011
product line
BioReagent
Quality Segment
assay
≥98% (agarose gel electrophoresis)
form
powder
mol wt
76-81 kDa
concentration
~25 mM
technique(s)
cell culture | mammalian: suitable
impurities
HIV and HBsAg, source material tested negative, endotoxin, tested
solubility
H2O: 50 mg/mL
cation traces
Fe: ≤0.005%
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... TF(7018)
General description
Transferrin, majorly synthesized in the liver, is an abundant glycoprotein in the serum. The members of the transferrin superfamily have similar polypeptide folding patterns. Transferrin contains N- and C-terminal iron-binding homologous domains. Each of these domains is split into two subdomains having binding sites for iron and anions within the inter-subdomain cleft. The binding cleft opens and closes with iron releasing and iron binding. apo-Transferrin is an iron-free protein that arises after transferrin dissociates from its receptor. This product can be supplemented with iron or used to bind free iron present in media.
Application
apo-Transferrin human has been used:
- to culture human primary pancreatic endothelial cells, Het1As (non-tumorous esophagus cells), and immortalized human colonic epithelial cells (HCEC-1CT)
- to culture α mouse liver 12 (AML-12) (mature hepatocytes) cells
- as a source for human apo-transferrin for purification before crystallography
Biochem/physiol Actions
Transferrin is responsible for transporting iron from the sites of absorption and storage to the tissue cells. It maintains the levels of iron in biological fluids. The levels of transferrin may indicate the total iron-binding capacity (TIBC). Transferrin supplies the required iron for incorporation into hemoglobin within RBCs in the bone marrow. Iron deficiency causes an increase in the levels of transferrin. Pregnancy and estrogen administration can also raise the levels of transferrin. Chronic liver disease, renal insufficiency, malnutrition, and protein-losing enteropathies reduce the synthesis of transferrin.
Other Notes
Non-heme iron-transport protein.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| description powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis) | description powder, ≥98% (agarose gel electrophoresis) | description powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis) | description γ-irradiated, powder, BioXtra, suitable for cell culture, ≥98% |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| form powder | form powder | form powder | form powder |
| shipped in ambient | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 50 mg/mL | solubility H2O: 50 mg/mL | solubility H2O: 50 mg/mL | solubility H2O: 50 mg/mL |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
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What is the carbohydrate content of human transferrin?
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