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T2573

Troglitazone

≥98% (HPLC), powder, PPARγ agonist

Synonym(s):

(±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045

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Size/SKUAvailabilityPrice
5 mg
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$196.00

About This Item

Empirical Formula (Hill Notation):
C24H27NO5S
CAS Number:
Molecular Weight:
441.54
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$196.00


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Product Name

Troglitazone, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: 20 mg/mL

SMILES string

Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3

InChI

1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)

InChI key

GXPHKUHSUJUWKP-UHFFFAOYSA-N

Gene Information

General description

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

Application

Troglitazone has been used as a reagent in adipocyte differentiation medium.

Biochem/physiol Actions

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles1. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α2.

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This Item
E6910G3295Y0001520
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

form

powder

form

powder

form

powder

form

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

-

solubility

DMSO: 20 mg/mL

solubility

DMSO: ≥10 mg/mL

solubility

H2O: insoluble, DMSO: >5 mg/mL

solubility

-

color

white to off-white

color

white to off-white

color

white

color

-

Gene Information

human ... PPARA(5465), PPARG(5468)

Gene Information

human ... PPARG(5468)

Gene Information

human ... PPARA(5465), PPARD(5467), PPARG(5468)

Gene Information

human ... PPARG(5468)


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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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