Key Documents

View All Documentation

Monoclonal Anti-TIS7 antibody produced in mouse

Name: Monoclonal Anti-TIS7 antibody produced in mouse
Brand: SIGMA
Price: 672 USD
Availability: InStock

~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Interferon-Related Developmental Regulator 1 (IFRD1) (human), Anti-PC4 (rat), Anti-TPA-Induced Sequence 7 (mouse)

Select a Size

Change View

Size/SKU	Availability	Price
200 μL	Available to ship TODAYfromMILWAUKEE	$672.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD08705605

Conjugate:

unconjugated

Clone:

IRT537, monoclonal

Application:

ARR, ELISA (i), ICC, WB

Citations:

$672.00

Available to ship TODAYDetails

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

IRT537, monoclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

mouse, human

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7

isotype

IgG2a

UniProt accession no.

O00458

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IFRD1(3475)
mouse ... Ifrd1(15982)
rat ... Ifrd1(29596)

Description

General description

The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.

Immunogen

synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.

Application

Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.

Biochem/physiol Actions

Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	P8999	P6749	P3487
Sigma-Aldrich T2576 Monoclonal Anti-TIS7 antibody produced in mouse	Sigma-Aldrich P8999 Anti-p53 antibody, Mouse monoclonal	Sigma-Aldrich P6749 Anti-p53 antibody, Mouse monoclonal	Sigma-Aldrich P3487 Monoclonal Anti-PTEN antibody produced in mouse
description ~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution	description clone DO-7, purified from hybridoma cell culture	description clone PAb1801, purified from hybridoma cell culture	description ~1 mg/mL, purified immunoglobulin, clone PTN-18, buffered aqueous solution
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity mouse, human	species reactivity human	species reactivity human	species reactivity mouse, human, rat
Gene Information human ... IFRD1(3475) mouse ... Ifrd1(15982) rat ... Ifrd1(29596)	Gene Information human ... TP53(7157)	Gene Information human ... TP53(7157)	Gene Information human ... PTEN(5728) mouse ... Pten(19211) rat ... Pten(50557)
clone IRT537, monoclonal	clone DO-7, monoclonal	clone PAb1801, monoclonal	clone PTN-18, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c