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Monoclonal Anti-Vitronectin antibody produced in mouse

Name: Monoclonal Anti-Vitronectin antibody produced in mouse
Brand: SIGMA
Price: 693 USD
Availability: InStock

clone VIT-2, ascites fluid

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0.2 mL	Check Cart for Availability	$693.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00162909

Conjugate:

unconjugated

Clone:

VIT-2, monoclonal

Application:

ARR, ELISA (i), IF, WB

Citations:

$693.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

VIT-2, monoclonal

mol wt

antigen 65-75 kDa

contains

15 mM sodium azide

species reactivity

human

technique(s)

indirect ELISA: suitable, indirect immunofluorescence: suitable using human cultured fibroblasts, microarray: suitable, western blot: 1:2,500 using a denatured and reduced preparation of purified human plasma vitronectin

isotype

IgM

UniProt accession no.

P04004

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VTN(7448)

Description

General description

Monoclonal Anti-Vitronectin (mouse IgM isotype) is derived from the VIT-2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified human plasma vitronectin. Vitronectin is also referred as serum-spreading factor, S-protein of complement or epibolin. This monomeric acidic protein is one of the major multifunctional cell-adhesive glycoproteins in mammalian plasma and serum. This protein is usually seen as a mixture of 75 kDa and 65 kDa polypeptides. Human plasma and serum contain 0.1-0.4 mg/ml of vitronectin which is synthesized in the liver. It is also present in amniotic fluid and urine.

Immunogen

human plasma vitronectin

Application

Monoclonal Anti-Vitronectin antibody produced in mouse has been used in:

immunocytochemisry
western blotting
immunoprecipitation
immunofluorescence
enzyme-linked immunosorbent assay (ELISA)

Biochem/physiol Actions

By immunoblotting, the product shows no cross-reactivity with fibronectin, laminin, merosin, collagen type IV or chondroitin sulfate types A, B and C.

Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b-9 complex. Vitronectin protects thrombin from inactivation by antithrombin III in the presence of heparin, binds and stabilizes the activity of plasminogen activator inhibitor and mediates many other physiological functions.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	V9131	F6140	F0916
Sigma-Aldrich V7881 Monoclonal Anti-Vitronectin antibody produced in mouse	Sigma-Aldrich V9131 Monoclonal Anti-Vinculin antibody produced in mouse	Sigma-Aldrich F6140 Monoclonal Anti-Fibronectin, Cellular antibody produced in mouse	Sigma-Aldrich F0916 Anti-Fibronectin antibody, Mouse monoclonal
description clone VIT-2, ascites fluid	description clone hVIN-1, ascites fluid	description clone FN-3E2, ascites fluid	description clone IST-4, purified from hybridoma cell culture
clone VIT-2, monoclonal	clone hVIN-1, monoclonal	clone FN-3E2, monoclonal	clone IST-4, monoclonal
Gene Information human ... VTN(7448)	Gene Information human ... VCL(7414) mouse ... Vcl(22330) rat ... Vcl(305679)	Gene Information human ... FN1(2335) mouse ... Fn1(14268)	Gene Information human ... FN1(2335)
species reactivity human	species reactivity frog, chicken, mouse, canine, human, bovine, rat, turkey	species reactivity mouse, human, chicken	species reactivity human
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid	antibody form purified from hybridoma cell culture
biological source mouse	biological source mouse	biological source mouse	biological source mouse

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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