This product is tested in a kinase assay using cdk2/cyclin A, active (14-448), to phosphorylate histone H1. The Certificate of Analysis contains the kinase assay procedure.
14-155
Histone H1 Protein, 20 mg
Purified bovine Histone H1 protein for use as a substrate in histone modification assays (HAT, HDAC, DNMT) and chromatin assembly studies.
Sinônimo(s):
Linker Histone H1
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Sobre este item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32
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Assistência Técnica
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Estamos aqui para ajudarfonte biológica
bovine
Nível de qualidade
peso molecular
Mw 32 kDa
fabricante/nome comercial
Upstate®
técnica(s)
activity assay: suitable (kinase)
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
1 of 4
Este Item | 05-1324 | H1917 | 06-1358 |
|---|---|---|---|
| technique(s) activity assay: suitable (kinase) | technique(s) immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable | technique(s) - | technique(s) dot blot: suitable, western blot: suitable |
| biological source bovine | biological source mouse | biological source human | biological source rabbit |
| mol wt Mw 32 kDa | mol wt - | mol wt - | mol wt - |
| shipped in dry ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
Descrição geral
H1 and related linker histones are important both for maintenance of higher-order chromatin structure and for the regulation of gene expression. Nucleosomal stabilization is provided through the binding of histone H1 to the nucleosomal dyad and the linker DNA entering and exiting the core particle. Additional experimental evidence illustrates the influence of histone H1 on chromatin arrangement and compaction. The family of histone H1 proteins contains five somatic variants (H1.1, H1.2, H1.3, H1.4 and H1.5) which are expressed in nearly all cell types.
Product Source: Lysine rich fraction from calf thymus
forma física
Sterilized through a 0.2 micron membrane filter
Nota de preparo
1 year at -20°C
Nota de análise
Routinely evaluated by Kinase assay using cdk2/cyclin A, active (14-448) to phosphorylate Histone H1.
Outras notas
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Hyo Kyun Chung et al.
The Journal of biological chemistry, 278(30), 28079-28088 (2003-04-30)
The Gadd45 family of proteins includes Gadd45alpha, MyD118/Gadd45beta, and CR6/OIG37/Gadd45gamma. These proteins play important roles in maintaining genomic stability and in regulating the cell cycle. This study reports the cloning of a novel protein called CR6-interacting factor 1 (CRIF1) which
J Pan et al.
Oncogene, 29(47), 6245-6256 (2010-08-31)
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2-knockout (Jdp2KO) mice by targeting exon-1
Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts.
Chellaiah, MA; Biswas, RS; Rittling, SR; Denhardt, DT; Hruska, KA
The Journal of Biological Chemistry null
B Ouyang et al.
The Journal of biological chemistry, 272(45), 28646-28651 (1997-11-14)
Human prk encodes a novel protein serine/threonine kinase capable of strongly phosphorylating casein but not histone H1 in vitro. prk expression is tightly regulated at various levels during different stages of the cell cycle in lung fibroblasts. The Prk kinase
Pim3 negatively regulates glucose-stimulated insulin secretion.
Gregory Vlacich,Martijn C Nawijn,Gene C Webb,Donald F Steiner
Islets null
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Hi can this be used for enzymatic assays?
1 answer-
Helpful?
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Sowohl die NCBI- als auch die Uni-Prot Nummer führen zu einer humanen Datenkarte, anstatt zu einer bovinen. Warum?
1 answer-
Thank you for notifying us about the mismatch. Please find the relevant links here:
https://www.ncbi.nlm.nih.gov/gene/617854
https://www.uniprot.org/uniprotkb/G3MWV5/entryHelpful?
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