A3262

Adenosine 3′,5′-cyclic monophosphate tris salt

Name: Adenosine 3′,5′-cyclic monophosphate tris salt
Brand: SIGMA
Price: 3072 BRL

≥97% (HPLC), synthetic, powder

Sinônimo(s):

cAMP, cyclic AMP

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500 MG

R$ 3.072,00

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Sobre este item

Fórmula empírica (Notação de Hill):

C₁₀H₁₂N₅O₆P · C₄H₁₁NO₃

Número CAS:

102029-77-6

Peso molecular:

450.34

Número MDL:

MFCD00058346

Código UNSPSC:

41106305

eCl@ss:

32160414

ID de substância PubChem:

329770822

NACRES:

NA.51

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Nome do produto

Adenosine 3′,5′-cyclic monophosphate tris salt, ≥97% (HPLC), powder

fonte biológica

synthetic

Nível de qualidade

200

Ensaio

≥97% (HPLC)

Formulário

powder

cor

white

solubilidade

H₂O: 100 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1

chave InChI

CLDDYJFNXTUHIN-MCDZGGTQSA-N

Categorias relacionadas

Phosphates

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Este Item	A9376	A0386	A9501
Sigma-Aldrich A3262 Adenosine 3′,5′-cyclic monophosphate tris salt	Sigma-Aldrich A9376 Adenosine 2′:3′-cyclic monophosphate sodium salt	Sigma-Aldrich A0386 Adenosine 3′-monophosphate sodium salt	Sigma-Aldrich A9501 Adenosine 3′,5′-cyclic monophosphate
biological source synthetic	biological source synthetic (organic)	biological source yeast	biological source -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
assay ≥97% (HPLC)	assay ≥93%	assay ≥98% (HPLC)	assay ≥98.5% (HPLC)
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
color white	color -	color -	color white

Descrição geral

Adenosine 3′,5′-cyclic monophosphate (cAMP) is synthesized from ATP in the presence of Adenylate cyclase enzyme. cAMP is majorly used as a marker in immunochemical detection assays.[1] Intracellular levels of cAMP control immune and inflammatory functions. Bacterial infection triggers intracellular cAMP production.[2] Elevated levels of cAMP modulates mitogen-activated protein kinase (MAPK) in cancer. An altered cAMP level is implicated in pathogenesis of cataract and cardiovascular disease. A decrease in cAMP levels triggers impaired insulin secretion in diabetes.[3]

Aplicação

Adenosine 3′,5′-cyclic monophosphate tris salt has been used as a medium supplement for human endometrial stromal cells (hESCs) culture[4] and induced neural stem cells (iNSCs).[5] It has been used in the spectroscopic characterization of pink flamindo, a red cAMP indicator.[6]

Ações bioquímicas/fisiológicas

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number

0000425160

0000364881

SLCF8554

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Cyclic AMP: master regulator of innate immune cell function

Serezani CH, et al.

American Journal of Respiratory Cell and Molecular Biology, 39(2), 127-132 (2008)

Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors

Tang X, et al.

Stem Cell Research, 16(2), 236-242 (2016)

Higenamine, a Dual Agonist for β 1- and β 2-Adrenergic Receptors Identified by Screening a Traditional Chinese Medicine Library.

Yanmin Chen et al.

Planta medica, 85(9-10), 738-744 (2019-06-12)

Chronic heart failure is the terminal stage of various cardiovascular diseases. Despite the availability of several classes of drugs, there is still an unmet need for effective treatment. Based on bench work during the past two decades, we have proposed

Targeted ablation of Wnt4 and Wnt5a in Müllerian duct mesenchyme impedes endometrial gland development and causes partial Müllerian agenesis.

Guillaume St-Jean et al.

Biology of reproduction, 100(1), 49-60 (2018-07-17)

Wnt4 and Wnt5a have well-established roles in the embryonic development of the female reproductive tract, as well as in implantation, decidualization, and ovarian function in adult mice. Although these roles appear to overlap, whether Wnt5a and Wnt4 are functionally redundant

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.

Joshua H K Tam et al.

Molecular brain, 7, 54-54 (2014-08-03)

Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid peptide (Aβ). Aβ is produced by sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Many studies have demonstrated that the internalization of APP from the cell

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Adenosine 3′,5′-cyclic monophosphate tris salt