This product is stored at room temperature.
C8895
Clofazimine
≥98% (TLC), powder, antimycobacterial rimonphenazine
Sinônimo(s):
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
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Sobre este item
Fórmula empírica (Notação de Hill):
C27H22Cl2N4
Número CAS:
Peso molecular:
473.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
217-980-2
MDL number:
Pular para
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Estamos aqui para ajudarNome do produto
Clofazimine,
form
powder
InChI key
WDQPAMHFFCXSNU-BGABXYSRSA-N
InChI
1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
SMILES string
CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
antibiotic activity spectrum
mycobacteria
mode of action
protein synthesis | interferes
originator
Novartis
Quality Level
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Categorias relacionadas
1 of 4
Este Item | BP663 | Y0000358 | C6628 |
|---|---|---|---|
| form powder | form solid | form - | form powder or crystals |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 200 |
| originator Novartis | originator - | originator - | originator - |
| antibiotic activity spectrum mycobacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum parasites |
| mode of action protein synthesis | interferes | mode of action - | mode of action - | mode of action enzyme | inhibits |
Application
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis.[7] Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus.[8] Clofazimine has immunosuppressive property.[9]
Preparation Note
This product is stored at room temperature.
Classe de armazenamento
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages
Keswani RK, et al.
Cytometry. Part A : the Journal of the International Society For Analytical Cytology, 87(9), 855-867 (2015)
An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 12-12 (2019)
In vitro approaches for generation of Mycobacterium tuberculosis mutants resistant to bedaquiline, clofazimine or linezolid and identification of associated genetic variants
Ismail N, et al.
Journal of Microbiological Methods, 153(8), 1-9 (2018)
Plumb's Veterinary Drug Handbook (2008)
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 3-3 (2019)
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At what temperature should this be stored? I so not see a specified temperature on label or SDS so I would assume room temperature but other manufacturers of this product claim -20C
1 answer-
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