Pular para o conteúdo
Merck

SML0235

CDPPB

≥98% (HPLC)

Sinônimo(s):

3-Cyano-N-1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Slide 1 of 1
Faça login para ver os preços organizacionais e de contrato.

Selecione um tamanho

Preço e disponibilidade não estão disponíveis no momento.

Sobre este item

Fórmula empírica (Notação de Hill):
C23H16N4O
Número CAS:
781652-57-1
Peso molecular:
364.40
UNSPSC Code:
12352200
PubChem Substance ID:
329825248
NACRES:
NA.77

Documentos Principais

Visualizar Toda a Documentação

Pular para

Assistência Técnica
Precisa de ajuda? Nossa equipe de cientistas experientes está à sua disposição.
Estamos aqui para ajudar

Nome do produto

CDPPB, ≥98% (HPLC)

SMILES string

O.O=C(Nc1cc(nn1-c2ccccc2)-c3ccccc3)c4cccc(c4)C#N

InChI

1S/C23H16N4O.H2O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20;/h1-15H,(H,25,28);1H2

InChI key

GZHZEGYXLNXEBV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥5 mg/mL at warmed to 60 °C

storage temp.

2-8°C

Quality Level

100

Categorias relacionadas

Comparar Itens Semelhantes

Ver Comparação Total

Mostrar diferenças

1 of 4

Este Item
SML0202SML1693SML1061
CDPPB ≥98% (HPLC)

Sigma-Aldrich

SML0235

CDPPB

DPH ≥98% (HPLC)

Sigma-Aldrich

SML0202

DPH

Pz-1 ≥98% (HPLC)

Sigma-Aldrich

SML1693

Pz-1

PF-04856264 ≥98% (HPLC)

Sigma-Aldrich

SML1061

PF-04856264

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥5 mg/mL at warmed to 60 °C

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 1 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to tan

color

white to beige

color

white to light brown

Application

CDPPB may be used in mGluR5-mediated cell signaling studies.

Biochem/physiol Actions

Activation of metabotropic glutamate 5 receptor by CDPPB enhances the function of NMDA receptor and markers of neuronal plasticity. This improves recognition memory and cognition deficits in schizophrenia.[1][2]
CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.
CDPPB is an mGluR5 positive allosteric modulator

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Classe de armazenamento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000480029
0000472321
0000472321
0000070249
0000070250

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Christina Gobin et al.
Psychopharmacology, 237(1), 115-125 (2019-08-26)
Cocaine use disorder (CUD) remains difficult to treat with no FDA-approved medications to reduce relapse. Antagonism of metabotropic glutamate receptor 5 (mGlu5) has been demonstrated to decrease cocaine-seeking but may also further compromise cognitive function in long-term cocaine users. Here we
Hyejin Lee et al.
PLoS biology, 17(6), e2005326-e2005326 (2019-06-06)
Netrin-G ligand-3 (NGL-3) is a postsynaptic adhesion molecule known to directly interact with the excitatory postsynaptic scaffolding protein postsynaptic density-95 (PSD-95) and trans-synaptically with leukocyte common antigen-related (LAR) family receptor tyrosine phosphatases to regulate presynaptic differentiation. Although NGL-3 has been
Jason M Uslaner et al.
Neuropharmacology, 57(5-6), 531-538 (2009-07-25)
In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic glutamate 5 receptor (mGluR5) activation enhances NMDA receptor activity, and in vivo experiments indicate that mGluR5 positive allosteric
Chi Ho Chong et al.
Translational psychiatry, 9(1), 244-244 (2019-10-05)
LRRC7 has been identified as a candidate gene for severe childhood emotional dysregulation. Direct experimental evidence for a role of LRRC7 in the disease is needed, as is a better understanding of its impact on neuronal structure and signaling, and
J G Doria et al.
British journal of pharmacology, 169(4), 909-921 (2013-03-16)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. We have previously demonstrated that the cell signalling of the metabotropic glutamate receptor 5 (mGluR5) is altered in a mouse model of
Exibir todos os documentos relacionados

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica