K3125

Kojisäure

≥98.5% (HPLC), powder, tyrosinase inhibitor

• Synonym(e): 2-Hydroxymethyl-5-hydroxy-γ-pyron, 5-Hydroxy-2-hydroxymethyl-4-pyranon, Cojisäure
• Empirische Formel (Hill-System): C₆H₆O₄
• CAS-Nummer: 501-30-4
• Molekulargewicht: 142.11
• NACRES: NA.77
• PubChem Substance ID: 24896226
• UNSPSC Code: 12352106
• EC Number: 207-922-4
• MDL number: MFCD00006580
• Beilstein/REAXYS Number: 120895

Eigenschaften

• Produktname: Kojisäure,
• InChI key: BEJNERDRQOWKJM-UHFFFAOYSA-N
• InChI: 1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
• SMILES string: OCC1=CC(=O)C(O)=CO1
• assay: ≥98.5% (HPLC)
• form: powder
• mp: 152-155 °C (lit.)
• Quality Level: 200

Beschreibung

Biochem/physiol Actions

Tyrosinase-Inhibitor.

Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics.[1] However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.[2]

Application

Kojic acid has been used:

• as an inhibitor of tyrosinase in guinea pigs pigmented hyperopic (PH)[3]
• as a reference inhibitor standard for screening tyrosinase inhibition[4]
• as a positive control for inhibition of tyrosinase in B16F10 melanoma cells[5]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)