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Merck

RRM1

ribonucleotide reductase M1

Sinónimos:
R1, RIR1, RR1
Especie:
ID UniProtKB:
ID del gen:
  • Human(6240) Summary: This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]
  • Mouse(20133) ribonucleotide reductase M1
  • Rat(685579) ribonucleotide reductase M1
  • chicken(419081) ribonucleotide reductase M1
  • Zebrafish(30740) ribonucleotide reductase M1 polypeptide
  • dog(476823) ribonucleotide reductase M1
  • cow(505537) ribonucleotide reductase M1
  • Horse(100053126) ribonucleotide reductase M1
  • domestic cat(101097343) ribonucleotide reductase M1
  • Domestic Rabbit(100345823) ribonucleotide reductase M1
  • sheep(101116171) ribonucleotide reductase M1
  • naked mole-rat(101708047) ribonucleotide reductase M1
  • domestic guinea pig(100728488) ribonucleotide reductase M1

Custom & Knockdown Gene Products

Antibodies

Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-RRM1 Antibody, clone 1E20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
affinity binding assay
flow cytometry

immunohistochemistry

western blot
Anti-RRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-RRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
Anti-RRM1 Antibody, clone 4P4U1, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot

Small Molecule - Inhibitor

Número de producto
Descripción
Especie
Hydroxyurea, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Hydroxycarbamide, European Pharmacopoeia (EP) Reference Standard,
Especie
human
Hydroxycarbamide, British Pharmacopoeia (BP) Reference Standard,
Especie
human
Hydroxyurea, 98%, powder,
Especie
human
Gemcitabine hydrochloride, ≥98% (HPLC),
Especie
human

esiRNA

Número de producto
Descripción
Especie
MISSION® esiRNA, targeting human RRM1,
Especie
human
MISSION® esiRNA, targeting mouse Rrm1,
Especie
mouse