07-374

Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody

Name: Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody
Brand: MM
Price: 361 EUR

Upstate^®, from rabbit

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A propos de cet article

Code UNSPSC :

12352203

eCl@ss :

32160702

Nomenclature NACRES :

NA.41

Principaux documents

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Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

mouse, human

Fabricant/nom de marque

Upstate^®

Technique(s)

western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_002253

Numéro d'accès UniProt

P35968

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

phosphorylation (pTyr1214)

Informations sur le gène

human ... KDR(3791)

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1 of 4

Cet article	07-819	04-894	07-278
Sigma-Aldrich 07-374 Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody	Sigma-Aldrich 07-819 Anti-phospho-EGFR (Tyr1148) Antibody	Sigma-Aldrich 04-894 Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal	Sigma-Aldrich 07-278 Anticorps anti-phospho-LAT (Tyr191)
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
clone polyclonal	clone polyclonal	clone D1W, monoclonal	clone polyclonal
species reactivity mouse, human	species reactivity human	species reactivity mouse, human	species reactivity human, mouse
antibody form purified antibody	antibody form affinity isolated antibody	antibody form culture supernatant	antibody form purified antibody
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
UniProt accession no. P35968	UniProt accession no. P00533	UniProt accession no. P35968	UniProt accession no. O43561

Description générale

200-230 kDa

Immunogène

(...FHpYDN...) in which pY corresponds to phosphorylated tyrosine at residue 1214 of human KDR/VEGFR2. Tyr1214 of human KDR corresponds to Tyr1212 in the mouse protein.

Application

Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody detects level of phospho-KDR/Flk-1/VEGFR2 (Tyr1214) & has been published & validated for use in WB.

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

Actions biochimiques/physiologiques

phospho-KDR/VEGFR2 (Tyr1214)

Forme physique

0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%

Format: Purified

Protein A purified

Notes préparatoires

2 years at -20°C

Remarque sur l'analyse

routinely evaluated by immunoblot RIPA lysates from porcine aortic endothelial cells expressing human CSF-1R/murineVEGFR-2 chimera

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

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Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation.

Meyer, Rosana D, et al.

Oncogene, 23, 5523-5531 (2004)

Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation.

V Dayanir et al.

The Journal of biological chemistry, 276(21), 17686-17692 (2001-03-30)

Activation of vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in vasculogenesis and angiogenesis. However, the mechanism by which VEGFR-2 activation elicits these cellular events is not fully understood. We recently constructed a chimeric receptor containing the extracellular

A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib.

Michael J Donovan et al.

European journal of cancer (Oxford, England : 1990), 45(8), 1518-1526 (2009-03-11)

To identify clinical and biometric features associated with overall survival of patients with advanced refractory non-small-cell lung cancer (NSCLC) treated with gefitinib. One hundred and nine diagnostic NSCLC samples were analysed for EGFR mutation status, EGFR immunohistochemistry, histologic morphometry and

The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules.

Rosana D Meyer et al.

The Journal of biological chemistry, 277(30), 27081-27087 (2002-05-25)

Vascular endothelial growth factor receptor (VEGFR)-2 plays a critical role in vasculogenesis during embryonic development and pathological angiogenesis, but little is known about the molecular mechanisms governing its functions. Here we investigated the role of tyrosine 1212 on mouse VEGFR-2

Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium.

Dellinger, MT; Brekken, RA

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