07-580

Anti-IKKε Antibody

Name: Anti-IKKε Antibody
Brand: MM
Price: 319 EUR

Upstate^®, from rabbit

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200 μG

319,00 €

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A propos de cet article

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

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Nom du produit

Anti-IKKε Antibody, Upstate^®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_014002

UniProt accession no.

Q14164

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... IKBKE(9641)
mouse ... Ikbke(56489)

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1 of 4

Cet article	05-631	SAB3500452	ZRB2032
Sigma-Aldrich 07-580 Anti-IKKε Antibody	Sigma-Aldrich 05-631 Anti-IKKγ Antibody	Sigma-Aldrich SAB3500452 Anti-IKKε antibody produced in rabbit	Sigma-Aldrich ZRB2032 Anti-IKKε Antibody, clone 1D7 ZooMAb^® Rabbit Monoclonal
species reactivity human, mouse	species reactivity mouse, human	species reactivity human	species reactivity human, mouse
clone polyclonal	clone monoclonal	clone polyclonal	clone 1D7, recombinant monoclonal
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
antibody form purified antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified antibody
technique(s) western blot: suitable	technique(s) western blot: suitable	technique(s) immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable
shipped in wet ice	shipped in wet ice	shipped in dry ice	shipped in ambient

Application

Research Category
Signaling

Research Sub Category
Immunological Signaling

This Anti-IKKε Antibody is validated for use in WB for the detection of IKKε.

Biochem/physiol Actions

IKKε

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Mr 80kDa

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 582-596 (SHLAKRLLQVFQEEC) of human IKKε

Physical form

Format: Purified

Protein A purified

of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Preparation Note

Stable for 2 years at -20°

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Classe de stockage

10 - Combustible liquids

wgk

WGK 1

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.

Vladimir V Kravchenko et al.

The Journal of biological chemistry, 278(29), 26612-26619 (2003-05-09)

We report that the product of the inducible gene encoding the kinase known as IKKi/IKKepsilon (IKKi) is required for expression of a group of genes up-regulated by pro-inflammatory stimuli such as bacterial endotoxin (lipopolysaccharide (LPS)). Here, using murine embryonic fibroblasts

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages.

Tina Ruggiero et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(9), 2898-2908 (2009-05-09)

The importance of post-transcriptional mechanisms for the regulation of the homoeostasis of the immune system and the response to challenge by microorganisms is becoming increasingly appreciated. We investigated the contribution of microRNAs (miRNAs) to macrophage activation induced by lipopolysaccharide (LPS).

Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer.

Lídia Hernandez et al.

Cancer research, 70(10), 4005-4014 (2010-04-29)

The NF-kappaB family of transcription factors has been implicated in the propagation of ovarian cancer, but the significance of constitutive NF-kappaB signaling in ovarian cancer is unknown. We hypothesized that constitutive NF-kappaB signaling defines a subset of ovarian cancer susceptible

Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer.

Congwen Wei et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(5), E601-E610 (2014-01-23)

Resistance to antiestrogens is one of the major challenges in breast cancer treatment. Although phosphorylation of estrogen receptor α (ERα) is an important factor in endocrine resistance, the contributions of specific kinases in endocrine resistance are still not fully understood.

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