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Merck

324410

Dynasore

≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®

Synonyme(s) :

Dynamin Inhibitor I, Dynasore, 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin

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A propos de cet article

Formule empirique (notation de Hill) :
C18H14N2O4
Numéro CAS:
304448-55-3
Poids moléculaire :
322.31
Numéro MDL:
MFCD00292551
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

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Nom du produit

Dynamin Inhibitor I, Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

pale yellow

Solubilité

DMSO: 16 mg/mL

Conditions d'expédition

ambient

Température de stockage

2-8°C

Chaîne SMILES 

N(\N=C\c3cc(c(cc3)O)O)C(=O)c1cc2c(cc1O)cccc2

InChI

1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

Clé InChI

SYNDQCRDGGCQRZ-VXLYETTFSA-N

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Cet article
324413324414324411
Dynamin Inhibitor I, Dynasore The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

324410

Dynamin Inhibitor I, Dynasore

Dynamin Inhibitor IV, Hydroxy-Dynasore The Dynamin Inhibitor IV, Hydroxy-Dynasore controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sigma-Aldrich

324413

Dynamin Inhibitor IV, Hydroxy-Dynasore

Dynamin Inhibitor V, 34-2 The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

324414

Dynamin Inhibitor V, 34-2

Dynamin Inhibitor II, MiTMAB The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

324411

Dynamin Inhibitor II, MiTMAB

form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥99% (HPLC)

assay

≥99% (titration)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic)

Description générale

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.

Conditionnement

Packaged under inert gas

Notes préparatoires

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Young, A., et al. 2009. Biochem. J., In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.
Macia. E., et al. 2006. Dev. Cell10, 839.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Toxicity: Environmental Hazard (N)

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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