NA29

Anti-p16 (Ab-1) Mouse mAb (DCS-50.1/H4)

Name: Anti-p16 (Ab-1) Mouse mAb (DCS-50.1/H4)
Brand: MM
Price: 463 EUR

liquid, clone DCS-50.1/H4, Calbiochem^®

Slide 1 of 1

Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

100 μG

463,00 €

Vérifier la disponibilité des articles du panier

Demander une commande groupée

A propos de cet article

NACRES:

NA.43

UNSPSC Code:

12352203

Principaux documents

Voir toute la documentation

Passer à

Service technique

Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.

Laissez-nous vous aider

Nom du produit

Anti-p16 (Ab-1) Mouse mAb (DCS-50.1/H4), liquid, clone DCS-50.1/H4, Calbiochem^®

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

DCS-50.1/H4, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem^®

storage condition

do not freeze

dilution

(Immunoblotting (0.5-5 µg/mL, )

isotype

IgG1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 4

Cet article	CC12	OP46	NA03
Sigma-Aldrich NA29 Anti-p16 (Ab-1) Mouse mAb (DCS-50.1/H4)	Sigma-Aldrich CC12 Anti-Cyclin D1 (Ab-3) Mouse mAb (DCS-6)	Sigma-Aldrich OP46 Anti-MDM2 (Ab-1) Mouse mAb (IF2)	Sigma-Aldrich NA03 Anti-PCNA (Ab-1) Mouse mAb (PC10)
biological source mouse	biological source mouse	biological source mouse	biological source mouse
antibody form purified antibody	antibody form purified antibody	antibody form purified antibody	antibody form purified antibody
species reactivity human	species reactivity human, mouse, rat	species reactivity human	species reactivity rat, yeast, mouse, human, zebrafish
clone DCS-50.1/H4, monoclonal	clone DCS-6, monoclonal	clone IF2, monoclonal	clone PC10, monoclonal
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
isotype IgG1	isotype IgG2a	isotype IgG2b	isotype IgG2a

Analysis Note

Negative Control
U2OS cells

Positive Control
Saos-2 cells or bladder tissue

Application

Immunoblotting (0.5-5 µg/ml, see application references)

Disclaimer

Toxicity: Standard Handling (A)

General description

Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with NS-2 mouse myeloma cells. Recognizes the ~16 kDa p16 protein.

Recognizes the ~16 kDa p16 protein in Saos-2 cells and bladder tissue. Sold under license of U.S. Patent 6,482,929. Sold under license of U.S. Patent 5,843,756, 6,090,578, and corresponding patents.

This Anti-p16 (Ab-1) Mouse mAb (DCS-50.1/H4) is validated for use in Immunoblotting for the detection of p16 (Ab-1).

Immunogen

Human

recombinant, human p16

Legal Information

Sold under license of U.S. Patents 5,843,756, 6,090,578 and corresponding patents.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Does not cross-react with the closely related p15 protein. Antibody should be titrated for optimal results in individual systems.

Koh, J., et al. 1995. Nature375, 506.
Lukas, J., et al. 1995. Nature375, 503.
Cheng, J.Q., et al. 1994. Cancer Res.54, 5547.
Jen, J., et al. 1994. Cancer Res.54, 6353.
Kamb, A., et al. 1994 Science264, 436.
Nobori, T., Miura, K., et al. 1994. Nature368, 753.
Okamoto, A., Demetrick, D.J., et al. 1994. Proc. Natl. Acad. Sci. USA91, 11045.
Serrano, M., et al. 1993. Nature366 704.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 0.05 M sodium phosphate buffer, 0.2% gelatin pH 7.5.

Vous ne trouvez pas le bon produit ?

Essayez notre Outil de sélection de produits.

Classe de stockage

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion.

Noriyasu Usami et al.

Oncogene, 22(39), 7923-7930 (2003-09-13)

We have found that a malignant mesothelioma cell line, NCI-H28, had a chromosome 3p21.3 homozygous deletion containing the beta-catenin gene (CTNNB1), which suggested that the deletion of beta-catenin might have a growth advantage in the development of this tumor. To

ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.

Goro Sashida et al.

Molecular and cellular biology, 29(13), 3687-3699 (2009-04-22)

Several ETS transcription factors, including ELF4/MEF, can function as oncogenes in murine cancer models and are overexpressed in human cancer. We found that Elf4/Mef activates Mdm2 expression; thus, lack of or knockdown of Elf4/Mef reduces Mdm2 levels in mouse embryonic

A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.

Jeffrey T Irelan et al.

PloS one, 4(4), e5067-e5067 (2009-04-03)

The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to identify novel transcriptional activators of

p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E.

J L Nargi et al.

Neoplasia (New York, N.Y.), 1(6), 544-556 (2000-08-10)

Epidemiological evidence has suggested an association between diets rich in antioxidants and diminished risks of various types of cancer. Proposed mechanisms for protective effects of antioxidants have involved inhibition of free radical-mediated DNA damage. Recent data suggest that antioxidants may

Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha.

Frederick Y Wu et al.

Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10683-10688 (2002-07-30)

Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic DNA virus that causes Kaposi sarcoma and AIDS-related primary effusion lymphoma (PEL). Here we show that KSHV lytic cycle replication in PEL cells induces G(1) cell cycle arrest, presumably to facilitate the progression

Afficher tous les articles scientifiques apparentés

Contenu apparenté

Caspases and other Apoptosis Related Tools Brochure

Questions

Évaluations

Aucune valeur de notation

Filtres actifs

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique