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Merck

41639

Diméthylsulfoxyde

BioUltra, Molecular Biology, ≥99.5% (GC)

Synonyme(s) :

DMSO, Sulfoxyde de méthyle

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A propos de cet article

Formule linéaire :
(CH3)2SO
Numéro CAS:
Poids moléculaire :
78.13
UNSPSC Code:
12191502
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-664-3
Beilstein/REAXYS Number:
506008
MDL number:
Grade:
Molecular Biology
Assay:
≥99.5% (GC)
Technique(s):
GC/GC: suitable
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)

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Nom du produit

Diméthylsulfoxyde, BioUltra, Molecular Biology, ≥99.5% (GC)

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

SMILES string

CS(C)=O

grade

Molecular Biology

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

product line

BioUltra

assay

≥99.5% (GC)

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

technique(s)

GC/GC: suitable

impurities

Dnases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected
≤0.001% free acid (as CH3COOH)

evapn. residue

≤0.005%

color

colorless

refractive index

n20/D 1.479 (lit.)
n20/D 1.479

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H2O: miscible (completely)

density

1.10 g/mL (lit.)

cation traces

Al: ≤0.5 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.5 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤1 mg/kg
Ni: ≤0.5 mg/kg
Pb: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

λ

neat

UV absorption

λ: 280 nm Amax: 0.22

suitability

suitable for molecular biology

Quality Level

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Cet article
D587941640-MPHR1309
assay

≥99.5% (GC)

assay

≥99.5%

assay

≥99.9% (GC)

assay

-

grade

for molecular biology

grade

-

grade

ACS reagent, puriss. p.a.

grade

certified reference material, pharmaceutical secondary standard

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

300

solubility

H2O: miscible (completely)

solubility

H2O: soluble(lit.), acetone: soluble(lit.), benzene: soluble(lit.), chloroform: soluble(lit.), ethanol: soluble(lit.)

solubility

-

solubility

-

form

liquid

form

liquid

form

liquid

form

-

vapor density

2.7 (vs air)

vapor density

2.7 (vs air)

vapor density

2.7 (vs air)

vapor density

-

Application

Le diméthylsulfoxyde (DMSO) a été utilisé comme véhicule de composés à tester dans diverses études expérimentales.[1][2] Il a également été utilisé comme solvant dans le protocole d'agrégation de l'amyloïdeβ (Aβ) pour la resolubilisation du peptide en vue de maintenir son état dissocié.[3]

Disclaimer

Refroidit facilement et revient doucement à la température de la pièce. Les produits solides peuvent être reliquéfiés par chauffage à la température ambiante sans abîmer le produit.

General description

Le diméthylsulfoxyde (DMSO) est un solvant aprotique efficace. C'est un produit incolore, inodore et hygroscopique. Le DMSO augmente la perméabilité de divers perméants hydrophiles et lipophiles.[4] C'est l'un des solvants couramment utilisés dans le laboratoire.[5]

Other Notes

Transfert génique assisté par polybrène/DMSO[6]

Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

The use of dimethylsulfoxide as a vehicle in cell culture experiments using ovarian carcinoma cell lines
Rodriguez-Burford C, et al.
Biotechniques, 78(1), 17-21 (2003)
Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons
Ungureanu A, et al.
Scientific reports, 6, 25841-25841 (2016)
R Aubin et al.
Methods in molecular biology (Clifton, N.J.), 7, 35-43 (1991-01-01)
Efforts to expand the current repertory of cell types amenable to transfection have often been thwarted by a common obstacle-namely, the low tolerance displayed by the recipient cells toward the gene-transfer regimen itself. As a result, several laboratories have turned
Topical and Transdermal Drug Delivery
Handbook of non-invasive drug delivery systems: science and technology (2009)
Developmental toxicity assay using high content screening of zebrafish embryos
Lantz-McPeak S, et al.
Journal of Applied Toxicology, 35(3), 261-272 (2015)

Contenu apparenté

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Questions

1–10 sur 11 questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is Sure/Seal™ packaging?

    1 réponse
    1. The Aldrich Sure/Seal™ packaging system is useful in the handling and storage of air-sensitive reagents.

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  4. Is Dimethyl sulfoxide a sterile product?

    1 réponse
    1. No, this product is not considered sterile.  Product Nos. D2560 and D2438 are sterile-filtered.

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  5. What type of filter is used to sterile-filter Dimethyl sulfoxide (DMSO)?

    1 réponse
    1. DMSO can be sterile-filtered through a 0.2 micron PTFE filter. The sterility testing is per the current US Pharmacopoeia method.

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  6. What is the molarity of DMSO?

    1 réponse
    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

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  7. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 réponse
    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

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  8. Does DMSO have any synthetic utility?

    1 réponse
    1. DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

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  9. What is the Department of Transportation shipping information for this product?

    1 réponse
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  10. What is the DMSO dissolved in?

    1 réponse
    1. DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

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