MTOXCE2E1
CypExpress™ 2E1 Cytochrome P450 human
Synonyme(s) :
CYP2E, CypP450 2E1, CPE1, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
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250 MG
279,00 €
1 G
629,00 €
10 G
4 710,00 €
A propos de cet article
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
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human
Produit recombinant
expressed in Pichia pastoris
Forme
dry powder
Température de stockage
−70°C
Informations sur le gène
human ... CYP2E1(1571)
1 of 4
Cet article | MTOXCE1A1 | MTOXCE1A2 | MTOXCE2D6 |
|---|---|---|---|
| recombinant expressed in Pichia pastoris | recombinant expressed in Pichia pastoris | recombinant expressed in Pichia pastoris | recombinant expressed in Pichia pastoris |
| biological source human | biological source human | biological source human | biological source human |
| form dry powder | form dry powder | form dry powder | form dry powder |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| Gene Information human ... CYP2E1(1571) | Gene Information human ... CYP1A1(1543) | Gene Information human ... CYP1A2(1544) | Gene Information human ... CYP2D6(1565) |
Actions biochimiques/physiologiques
Cytochrome P450 enzymes are heme containing monooxygenases which are found primarily in the mammalian liver. They catalyze the oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. The gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.
Caractéristiques et avantages
CypExpress™ 2E1 is a permeabilized and stabilized dried yeast powder preparation containing full length, unmodified, human CYP 2E1 and recombinant human NADPH oxidoreductase. Using proprietary processes, CypExpress™ are expressed in Pichia yeast. Following optimal expression, the cells are inactivated, permeabilized and dried to a fine powder. CypExpress™ retains the cellular mechanisms to provide the P450 enzymes with the energy and cofactors to continue to function for long experiments, and can generate larger amounts of metabolite than mammalian microsomes or other genetically engineered expression systems.It is designed for rapid screening of drug metabolites and for scaling up metabolite generation.
Informations légales
CypExpress is a trademark of Oxford Biomedical Research
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Arij Ben Chaaben et al.
Bulletin du cancer, 102(12), 967-972 (2015-11-20)
Cytochrome P450 2E1 (CYP2E1) is a detoxifying enzyme that belongs to the phase I metabolism of xenobiotics. This enzyme is encoded by a highly polymorphic gene whose common polymorphism corresponds to the substitution of cytosine (C) and thymine (T) at
Yan Tang et al.
In vivo (Athens, Greece), 28(6), 1077-1084 (2014-11-16)
Cytochrome P450 2E1 (CYP2E1) has active roles in bioconversion and biotransformation in humans. Although predominantly present in hepatocytes, CYP2E1 has also been found in hematopoietic stem cells and subtypes of acute myeloid leukemia with unknown clinical significance except for the
Mridul Malakar et al.
Asian Pacific journal of cancer prevention : APJCP, 15(20), 8815-8822 (2014-11-07)
The incidence of stomach cancer in India is highest in the state of Mizoram. In this population based matched case-control study, we evaluated the relationship between CYP450 2E1 RsaI polymorphism and risk of stomach cancer taking into considering various important
Flores Naselli et al.
Gene, 536(1), 29-39 (2013-12-18)
Different individuals possess slightly different genetic information and show genetically-determined differences in several enzyme activities due to genetic variability. Following an integrated approach, we studied the polymorphisms and methylation of sites contained in the 5' flanking region of the metabolizing
Octavio Jiménez-Garza et al.
Toxicology and applied pharmacology, 286(3), 207-215 (2015-05-13)
CYP2E1 is a versatile phase I drug-metabolizing enzyme responsible for the biotransformation of most volatile organic compounds, including toluene. Human toluene exposure increases CYP2E1 mRNA and modifies its activity in leucocytes; however, epigenetic implications of this interaction have not been
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