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Merck

14-917-M

CLK4 Protein, active, 10 µg

Active, N-terminal 6His-tagged, recombinant, human CLK4, amino acids 128-end, for use in Kinase Assays.

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14-917

454,00 €

14-917M

3.610,00 €

454,00 €

Spedizione prevista il05 gennaio 2026Dettagli

Informazioni su questo articolo

Codice UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32

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Origine biologica

human

Livello qualitativo

100
300

Ricombinante

expressed in baculovirus infected Sf21 cells

PM

Mw 46 kDa

Produttore/marchio commerciale

Upstate®

tecniche

activity assay: suitable (kinase)

N° accesso NCBI

NM_020666

N° accesso UniProt

Q9HAZ1

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Questo articolo
14-920-M14-774-M23-041-M
CLK4 Protein, active, 10 µg Active, N-terminal 6His-tagged, recombinant, human CLK4, amino acids 128-end, for use in Kinase Assays.

Sigma-Aldrich

14-917-M

CLK4 Protein, active, 10 µg

CLK1, active

Sigma-Aldrich

14-920-M

CLK1, active

CLK2 Protein, active, 10 µg Active, N-terminal GST-tagged, recombinant, human, CLK2, amino acids 138-end. For use in Kinase Assays.

Sigma-Aldrich

14-774-M

CLK2 Protein, active, 10 µg

c-Cbl Protein, active, 10 µg Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Sigma-Aldrich

23-041-M

c-Cbl Protein, active, 10 µg

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

-

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

biological source

human

biological source

human

biological source

human

biological source

human

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable

mol wt

Mw 46 kDa

mol wt

Mw 45 kDa

mol wt

Mw 70.4 kDa

mol wt

-

UniProt accession no.

Q9HAZ1

UniProt accession no.

P49759

UniProt accession no.

O35491 (mouse), P49760

UniProt accession no.

-

NCBI accession no.

NM_020666

NCBI accession no.

NM_004071

NCBI accession no.

NM_003993

NCBI accession no.

NM_005188

Descrizione generale

CLK4 protein belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
Product Source: N-terminal 6His-tagged, recombinant, human CLK4 amino acids 128-end expressed by baculovirus in Sf21 insect cells.

Applicazioni

Research Category
Signaling

Azioni biochim/fisiol

Protein Target: CLK4
Target Sub-Family: CMGC

Confezionamento

Also available in 250μg size as catalog # 14-917M and in bulk as catalog # 14-917-K.

Stato fisico

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Purified using immobilized metal affinity chromatography.

Nota sulla preparazione

6 months at -70°C

Risultati analitici

Routinely evaluated by phosphorylation of peptide YRRAAVPPSPSLSRHSSPHQS(p)EDEEE.

Altre note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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