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Merck

AB3852

Anti-Cortactin Antibody, phospho-specific (Tyr421)

Chemicon®, from rabbit

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100 μG

338,00 €

338,00 €


Spedizione prevista il27 gennaio 2026Dettagli


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Informazioni su questo articolo

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

human, rat

Produttore/marchio commerciale

Chemicon®

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

phosphorylation (pTyr421)

Informazioni sul gene

human ... CTTN(2017)

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Questo articolo
SAB4504372HPA057242MABT524
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

Gene Information

human ... CTTN(2017)

Gene Information

human ... CTTN(2017)

Gene Information

human ... CTTN(2017)

Gene Information

human ... CTTN(2017)

species reactivity

human, rat

species reactivity

human, mouse, rat

species reactivity

human

species reactivity

mouse

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

ambient

Immunogeno

Epitope: phospho-specific (Tyr421)
Rabbit anti-Cortactin (Y421) polyclonal antibody was raised against a peptide corresponding to residues surrounding phosphorylated Y421of human cortactin.

Applicazioni

Anti-Cortactin Antibody, phospho-specific (Tyr421) detects level of Cortactin & has been published & validated for use in WB.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton
Western blot: 1-2 μg/mL

Optimal working dilutions must be determined by end user.

Azioni biochim/fisiol

Recognizes Cortactin phosphorylated on tyrosine 421. Cortactin is an 80-85 kDa actin-binding protein, which consists of a variety of protein domains. The nature and function of these domains, coupled with the presence of multiple consensus sites for phosphorylation by tyrosine and serine/threonine kinases, suggests that cortactin integrates activation of specific signaling pathways with cytoskeletal reorganization.

Stato fisico

Affinity purified immunoglobulin. Liquid in 1mg/mL in PBS with 0.1% Sodium azide.

Nota sulla preparazione

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months after receipt.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Hippocampal Cortactin Levels are Reduced Following Spatial Working Memory Formation, an Effect Blocked by Chronic Calpain Inhibition.
Olson, ML; Ingebretson, AE; Harmelink, KM
Brain sciences null
Jakob Knorr et al.
European journal of microbiology & immunology, 10(1), 20-27 (2020-05-05)
The gastric pathogen Helicobacter pylori colonizes approximately half of the human world population. The bacterium injects the effector protein cytotoxin associated gene A (CagA) via a type-IV secretion system into host epithelial cells, where the protein becomes phosphorylated at specific
Yu Yu et al.
Oncogene, 37(28), 3778-3789 (2018-04-13)
Cell motility and invasiveness are prerequisites for dissemination, and largely account for cancer mortality. We have identified an actionable kinase, spleen tyrosine kinase (SYK), which is keenly tightly associated with tumor progression in ovarian cancer. Here, we report that active
Nayden G Naydenov et al.
Cells, 11(9) (2022-05-15)
Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer (CAC). The altered structure of epithelial cell-cell adhesions
Lizandra Jimenez et al.
Archives of pathology & laboratory medicine, 139(11), 1349-1361 (2015-07-15)
Head and neck squamous cell carcinoma (HNSCC) is a highly invasive cancer with an association with locoregional recurrence and lymph node metastasis. We have previously reported that low microRNA-375 (miR-375) expression levels correlate with poor patient survival, increased locoregional recurrence

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