AB5849

Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

Name: Anti-Glutamate Receptor 1 Antibody, phosphoSer 845
Brand: MM

Chemicon^®, from rabbit

Sinonimo/i:

GluR1

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Informazioni su questo articolo

Codice UNSPSC:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rat

Confezionamento

antibody small pack of 25 μL

Produttore/marchio commerciale

Chemicon^®

tecniche

western blot: suitable

N° accesso NCBI

NM_000827.2

N° accesso UniProt

P42261

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

phosphorylation (pSer845)

Informazioni sul gene

human ... GRIA1(2890)

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Questo articolo	AB5847	MABN832	SAB5700489
Sigma-Aldrich AB5849 Anti-Glutamate Receptor 1 Antibody, phosphoSer 845	Sigma-Aldrich AB5847 Anti-Glutamate Receptor 1 Antibody, phosphoSer 831	Sigma-Aldrich MABN832 Anti-pan-AMPA receptor (GluR1-4), clone 2D8 Antibody	Sigma-Aldrich SAB5700489 Anti-Phospho-GRIA1-S845 antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
antibody form affinity purified immunoglobulin	antibody form affinity purified immunoglobulin	antibody form purified antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
species reactivity rat	species reactivity rat	species reactivity human, rat	species reactivity mouse, human, rat
Gene Information human ... GRIA1(2890)	Gene Information human ... GRIA1(2890)	Gene Information human ... GRIA1(2890)	Gene Information human ... GRIA1(2890)
technique(s) western blot: suitable	technique(s) western blot: suitable	technique(s) ELISA: suitable, electron microscopy: suitable, immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable	technique(s) western blot: 1:500-1:2000

Descrizione generale

100 kDa

Glutamate receptor 1 (AMPA) belongs to the glutamate-gated ion channel and binds AMPA, glutamate and kainate. L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS, acting through both ligand gated ion channels (ionotropic receptors; composed of subunits GluR1-4) and G-protein coupled (metabotropic) receptors. The AMPA glutamate receptors mediate fast synaptic transmission in the CNS.

Immunogeno

Epitope: phosphoSer 845

Synthetic peptide corresponding to amino acids surrounding the phosphoSer845 of rat GluR1.

Applicazioni

Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is an antibody against Glutamate Receptor 1 for use in WB.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Western blot: 1:1,000

Optimal working dilutions must be determined by the end user.

Azioni biochim/fisiol

Recognizes Glutamate Receptor 1 [GluR1], phosphoSe845. The antibody recognizes a protein of 100 kDa corresponding to GluR1 phosphorylated at Ser845.

Stato fisico

Affinity Purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

ImmunoAffinity Purified

Nota sulla preparazione

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
Human brain tissue

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Enhanced cocaine-conditioned place preference and associated brain regional levels of BDNF, p-ERK1/2 and p-Ser845-GluA1 in food-restricted rats.

Shan Liu et al.

Brain research, 1400, 31-41 (2011-06-07)

Previously, a learning-free measure was used to demonstrate that chronic food restriction (FR) increases the reward magnitude of a wide range of abused drugs. Moreover, a variety of striatal neuroadaptations were detected in FR subjects, some of which are known

Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation.

Shukla, K; Kim, J; Blundell, J; Powell, CM

The Journal of Biological Chemistry null

Effects of food restriction on expression of place conditioning and biochemical correlates in rat nucleus accumbens.

Caroline Jung et al.

Psychopharmacology, 233(17), 3161-3172 (2016-07-05)

When ad libitum-fed rats undergo cocaine place preference conditioning (CPP) but are switched to food restriction for testing, CPP becomes resistant to extinction and correlates with phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 at Ser845 in nucleus accumbens (NAc) core.

Insulin receptor activation in the nucleus accumbens reflects nutritive value of a recently ingested meal.

C A Woods et al.

Physiology & behavior, 159, 52-63 (2016-03-19)

With respect to feeding, insulin is typically thought of as a satiety hormone, acting in the hypothalamus to limit ingestive behavior. However, accumulating evidence suggests that insulin also has the ability to alter dopamine release in the striatum and influence

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression.

Xiang Cai et al.

Nature neuroscience, 16(4), 464-472 (2013-03-19)

The causes of major depression remain unknown. Antidepressants elevate concentrations of monoamines, particularly serotonin, but it remains uncertain which downstream events are critical to their therapeutic effects. We found that endogenous serotonin selectively potentiated excitatory synapses formed by the temporoammonic

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Contenuto correlato

RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer845 AFFINITY PURIFIED POLYCLONAL ANTIBODY

Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

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