This product is not tested for moisture content.
17850
Ciprofloxacin
≥98% (HPLC)
Ciprofloxacin
Sinonimo/i:
1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, Ciprobay
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5 G
39,20 €
25 G
162,00 €
39,20 €
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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C17H18FN3O3
Numero CAS:
Peso molecolare:
331.34
Beilstein:
3568352
Numero MDL:
Codice UNSPSC:
41116105
ID PubChem:
NACRES:
NA.21
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Permettici di aiutartiagenzia
EPA 1694
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder or crystals
Spettro attività antibiotica
Gram-negative bacteria
Gram-positive bacteria
applicazioni
environmental
Modalità d’azione
DNA synthesis | interferes
enzyme | inhibits
Stringa SMILE
OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
InChI
1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
MYSWGUAQZAJSOK-UHFFFAOYSA-N
Informazioni sul gene
human ... CYP1A2(1544), KCNH1(3756)
rat ... Gabra1(29705)
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Categorie correlate
1 of 4
Questo articolo | 33434 | Y0000198 | 1134313 |
|---|---|---|---|
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level - |
| form powder or crystals | form - | form - | form - |
| application(s) environmental | application(s) agriculture | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
Descrizione generale
Ciprofloxacin is a second-generation broad-spectrum fluoroquinolone antibiotic with extensive antimicrobial and pharmacokinetic properties that is widely used to combat bacterial infections. Its chemical name is 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid.[1][2]
Chemical structure: fluoroquinolone
Chemical structure: fluoroquinolone
Applicazioni
Ciprofloxacin is widely used in clinical practices against Gram-positive and Gram-negative bacteria and the treatment of a broad range of infections, including those of the skin, eyes, urinary tract, lower respiratory tract, gastrointestinal tract, et cetera. It can also be combined with various antimicrobial agents to combat bacterial biofilms as well as multidrug-resistant microorganisms.[1] Its derivatives have been developed to synthesize novel antibacterials with enhanced potency and diverse antimicrobial effects including antibacterial, antifungal, anti-HIV, anti-tumor, and anti-TB properties.[2]
Azioni biochim/fisiol
The mechanism of action of Ciprofloxacin is the inhibition of bacterial DNA synthesis by blocking the subunit A of DNA gyrase enzyme as well as by affecting the bacterial cell wall.[1]
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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is this the anhydrous form of ciprofloxacin?
1 risposta-
Utile?
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Is Ciprofloxacin HCL available and is it USP grade?
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Product 17850 has a molecular formula of C17H18FN3O3. The form of the chemical being searched for would have a molecular formula of C17H18FN3O3.HCL,H2O. There is Ciprofloxacin HCL.H2O but only in very small quantities as a secondary pharmaceutical standard, with the catalog number PHR1044. Regarding the question about whether the products are USP grade, the answer is no. Both products are labeled as strictly for Research Use Only and, as such, are not suitable for human use.
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Hi. Should I keep ciprofloxacin 17850-5g in refrigerator or -20? Thank you
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In the powder form, this product is to be stored at tightly closed at room temperature. Solutions prepared in 1% HCl at 1 mg/ml may be stored in frozen aliquots at -20 °C for up to 12 months.
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What are the storage conditions of this product?
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This product is to be stored at room temperature.
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17850 Sigma-Aldrich Ciprofloxacin How much is the measured water content and active fraction of the above product?
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This product is not tested for moisture content or potency/activity. The minimum purity of this product is 98% by HPLC. A similar product, PHR1167, is tested for loss on drying, but not potency/activity. This product typically demonstrates a >99% purity as compared to the USP and EP standards. See the link below to review this product option:
https://www.sigmaaldrich.com/US/en/product/sial/phr1167Utile?
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If a stock solution of Cipro 17850 is solved in 0,1 HCl, at what temperature should it be stored and how long ist it stable?
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Unfortunately, stability studies have not been performed on this product. However, several papers have information on the solution stability of ciprofloxacin.
(1) Stock solutions of ciprofloxacin in water at 200 mg/L, 100 mg/L, 40 mg/L, 20 mg/L and 4 mg/L can be stored at -20 °C for "at least 60 days.
http://www.clinchem.org/cgi/reprint/31/5/684.pdf
(2) Stock solutions of ciprofloxacin at 1 mg/mL in 1% HCl can be stored at -20 °C for at least 12 months.
http://onlinelibrary.wiley.com/doi/10.1002/bmc.1523/fullUtile?
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Is ciprofloxacin 17850 soulable in water
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This product is soluble in DMSO (<1 mg/ml at 25° C), methanol, 0.1N hydrochloric acid (25 mg/ml), and ethanol (<1 mg/ml at 25° C). It is insoluble in water.
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What is the solubility of Product 17850, Ciprofloxacin?
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17850 is the free base of ciprofloxacin. It is soluble in 0.1N HCl at 25 mg/ml. Ciprofloxacin is poorly soluble in DMSO. For HPLC, dissolve the sample material in a mixture ofAcetonitril/Phosphoric acid pH 2.4 by ultrasonification (5 mg/10 ml solvent).
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What is the potency of Product 17850, Ciprofloxacin?
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The potency of this product has not been determined by our Quality Control or by our supplier.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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