P1750000

Pimozide

Name: Pimozide
Brand: SIAL
Price: 113 EUR

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

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150 MG

113,00 €

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₈H₂₉F₂N₃O

Numero CAS:

2062-78-4

Peso molecolare:

461.55

NACRES:

NA.24

PubChem Substance ID:

329820105

UNSPSC Code:

41116107

MDL number:

MFCD00055081

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Nome del prodotto

Pimozide, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)

SMILES string

Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5

InChI key

YVUQSNJEYSNKRX-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

pimozide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356)

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Questo articolo	BP682	1539508	PHR3223
P1750000 Pimozide	BP682 Pimozide	USP 1539508 Pimozide	Supelco PHR3223 Pimozide
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard
manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename USP	manufacturer/tradename -
format neat	format neat	format neat	format -
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical
API family pimozide	API family pimozide	API family pimozide	API family -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. -

Application

Pimozide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

related product

N° Catalogo

Descrizione

Determinazione del prezzo

1539508

Pimozide, United States Pharmacopeia (USP) Reference Standard

BP682

Pimozide, British Pharmacopoeia (BP) Reference Standard

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Pimozide: a review of its pharmacological properties and therapeutic uses in psychiatry.

R M Pinder et al.

Drugs, 12(1), 1-40 (1976-01-01)

Pimozide 1-(1-[4,4-bis(4-fluorophenyl)butyl]-4-peperidinyl)-2-benzimidazolone, is the first of a new series of psychotropic drugs, the kiphenylbutylpiperidines. It is advocated for once-daily use as maintenance therapy in chronic schizophrenia and for the treatment of psychic and functional disorders induced by personality traits. Published

Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.

C Sprissler et al.

Blood cancer journal, 4, e240-e240 (2014-08-26)

The spleen tyrosine kinase (SYK) was identified as an oncogenic driver in a broad spectrum of hematologic malignancies. The in vivo comparison of three SYK containing oncogenes, SYK(wt), TEL-SYK and IL-2-inducible T-cell kinase (ITK)-SYK revealed a general myeloexpansion and the

The role of pimozide in clinical psychiatry: a review.

L A Opler et al.

The Journal of clinical psychiatry, 52(5), 221-233 (1991-05-01)

Pimozide, a diphenylbutylpiperidine neuroleptic which is FDA-approved as a backup treatment for Gilles de la Tourette's syndrome, has been used abroad for many years as a treatment of schizophrenia and has been recently reported to be particularly effective in treating

Pimozide for schizophrenia or related psychoses.

Meghana Mothi et al.

The Cochrane database of systematic reviews, 11(11), CD001949-CD001949 (2013-11-07)

Pimozide, formulated in the 1960s, continues to be marketed for the care of people with schizophrenia or related psychoses such as delusional disorder. It has been associated with cardiotoxicity and sudden unexplained death. Electrocardiogram monitoring is now required before and

Pimozide: use in Tourette's syndrome.

C L Colvin et al.

Drug intelligence & clinical pharmacy, 19(6), 421-424 (1985-06-01)

The orphan drug pimozide was recently approved for marketing in the U.S. for the treatment of Tourette's syndrome (TS). TS is characterized by recurrent, involuntary motor movements and vocal tics, and is believed to be due to neurochemical dysfunction. Pimozide's

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