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Merck

P9879

Procaine hydrochloride

≥97% (HPLC), powder, Na⁺ channel blocker

Sinonimo/i:

4-Aminobenzoic acid 2-diethylaminoethyl ester, p-Aminobenzoic acid diethylaminoethyl ester hydrochloride, Novocaine hydrochloride

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50 G

37,80 €

100 G

68,10 €

250 G

143,00 €

37,80 €

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Informazioni su questo articolo

Formula condensata:
H2NC6H4CO2CH2CH2N(C2H5)2·HCl
Numero CAS:
51-05-8
Peso molecolare:
272.77
NACRES:
NA.77
PubChem Substance ID:
24278665
UNSPSC Code:
12352200
EC Number:
200-077-2
MDL number:
MFCD00013000
Beilstein/REAXYS Number:
3917802

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Nome del prodotto

Procaine hydrochloride, ≥97%

InChI key

HCBIBCJNVBAKAB-UHFFFAOYSA-N

InChI

1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

SMILES string

Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1

assay

≥97%

form

powder

mp

155-156 °C (lit.)

originator

Celgene

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Questo articolo
1564006P31000001561008
Procaine hydrochloride ≥97%

Sigma-Aldrich

P9879

Procaine hydrochloride

Procaine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1564006

Procaine hydrochloride

Procaine hydrochloride European Pharmacopoeia (EP) Reference Standard

P3100000

Procaine hydrochloride

Prilocaine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1561008

Prilocaine hydrochloride

form

powder

form

-

form

-

form

-

assay

≥97%

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

originator

Celgene

originator

-

originator

-

originator

-

mp

155-156 °C (lit.)

mp

155-156 °C (lit.)

mp

155-156 °C (lit.)

mp

-

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Application

Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length.[1] It has also been used as an inducer in M9 media for induction assay.[2]

Biochem/physiol Actions

Procaine is a Na+ channel blocker, commonly used as an anesthetic agent and is considered safer than cocaine.[3] It is also useful as a painkiller to treat pain, associated with joints and tendons.[4]

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000504519
0000504519
0000455498
0000455497
0000455497

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Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli
Clarke EJ and Voigt CA
Biotechnology and Bioengineering, 108(3), 666-675 (2011)
Phillippe P Gonzalez et al.
Glia, 66(5), 999-1015 (2018-02-03)
Malignant glioma is one of the deadliest types of cancer. Understanding how the cell of origin progressively evolves toward malignancy in greater detail could provide mechanistic insights and lead to novel concepts for tumor prevention and therapy. Previously we have
J Dudel et al.
Journal of neurophysiology, 81(5), 2386-2397 (1999-05-13)
of quantal end-plate currents of mouse muscle by physostigmine and procaine. Quantal endplate currents (qEPCs) were recorded from hemidiaphragms of mice by means of a macro-patch-clamp electrode. Excitation was blocked with tetrodotoxin, and quantal release was elicited by depolarizing pulses
Ophthalmic Anaesthesia, 5-5 (2002)
Laura Pastorino et al.
Materials science & engineering. C, Materials for biological applications, 76, 1129-1135 (2017-05-10)
In this work, novel chitosan based microparticles were developed by the layer-by-layer deposition of poly(lactic acid) stereocomplex films on their surface in the view of controlling the release of encapsulated hydrophilic drugs. As first step, the quartz crystal microbalance technique
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