SML0599

DIF-1

Name: DIF-1
Brand: SIGMA
Price: 116.45 EUR

≥98% (HPLC)

Sinonimo/i:

1-(3,5-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-Hexanone

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₃H₁₆Cl₂O₄

Numero CAS:

111050-72-7

Peso molecolare:

307.17

UNSPSC Code:

12352200

NACRES:

NA.77

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Nome del prodotto

DIF-1, ≥98% (HPLC)

SMILES string

Clc1c(c(c(c(c1O)C(=O)CCCCC)O)Cl)OC

InChI

1S/C13H16Cl2O4/c1-3-4-5-6-7(16)8-11(17)9(14)13(19-2)10(15)12(8)18/h17-18H,3-6H2,1-2H3

InChI key

VUDQSRFCCHQIIU-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

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Mostra le differenze

1 of 4

Questo articolo	SML1274	D0567	SML2226
Sigma-Aldrich SML0599 DIF-1	Sigma-Aldrich SML1274 RI-1	Sigma-Aldrich D0567 DIF-3	Sigma-Aldrich SML2226 BC-LI-0186
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥99% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C
solubility DMSO: 20 mg/mL, clear	solubility DMSO: 10 mg/mL, clear	solubility DMSO: soluble 46 mg/mL	solubility DMSO: 2 mg/mL, clear
color white to beige	color yellow to orange	color -	color white to beige

Biochem/physiol Actions

DIF-1 (differentiation-inducing factor-1) is isolated from a Dictyostelium slime mold, and is used to inhibit proliferation/promote differentiation in various cell lines.

DIF-1 is a cell differentiation inducing factor.

DIF-1 is a cell differentiation inducing factor.
Differentiation-inducing factor-1 (DIF-1) blocks the migration and invasion of cells and decreases the expression of matrix metalloproteinase-2. It prevents the proliferation of cells using glycogen synthase kinase-3 (GSK-3)-dependent mechanism.[1] DIF-1 is more active when compared to DIF-2 in promoting stalk cell differentiation under submerged assay conditions.[2]

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Migration of Dictyostelium slugs: anterior-like cells may provide the motive force for the prespore zone.

Jean-Paul Rieu et al.

Cell motility and the cytoskeleton, 66(12), 1073-1086 (2009-08-21)

The collective motion of cells in a biological tissue originates from their individual responses to chemical and mechanical signals. The Dictyostelium slug moves as a collective of up to 100,000 cells with prestalk cells in the anterior 10-30% and prespore

[Low molecular compounds that regulate cell differentiation and chemotaxis in Dictyostelium discoideum].

Yuzuru Kubohara et al.

Seikagaku. The Journal of Japanese Biochemical Society, 82(12), 1132-1137 (2011-02-26)

Atg1 allows second-signaled autophagic cell death in Dictyostelium.

Marie-Françoise Luciani et al.

Autophagy, 7(5), 501-508 (2011-02-09)

We investigated the role of Atg1 in autophagic cell death (ACD) in a Dictyostelium monolayer model. The model is especially propitious, not only because of genetic tractability and absence of apoptosis machinery, but also because induction of ACD requires two

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation.

Christopher Sugden et al.

Developmental biology, 353(2), 290-301 (2011-03-15)

Dictyostelium is the only non-metazoan with functionally analyzed SH2 domains and studying them can give insights into their evolution and wider potential. LrrB has a novel domain configuration with leucine-rich repeat, 14-3-3 and SH2 protein-protein interaction modules. It is required

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1.

Christopher S Neumann et al.

Proceedings of the National Academy of Sciences of the United States of America, 107(13), 5798-5803 (2010-03-17)

Differentiation-inducing factor 1 (DIF-1) is a polyketide-derived morphogen which drives stalk cell formation in the developmental cycle of Dictyostelium discoideum. Previous experiments demonstrated that the biosynthetic pathway proceeds via dichlorination of the precursor molecule THPH, but the enzyme responsible for

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DIF-1