DCA Deblock(0.36 M ジクロロ酢酸トルエン溶液)

Name: DCA Deblock(0.36 M ジクロロ酢酸トルエン溶液)
Brand: ALDRICH
Price: 46100 JPY

別名:

DEBLOCK(0.36 M ジクロロ酢酸トルエン溶液)

Slide 1 of 1

ログインで組織・契約価格をご覧ください。

サイズを選択してください

4 X 4 L

￥46,100

単価￥92,200割引50%

カートの在庫状況を確認する

バルクの問い合わせ

この商品について

実験式（ヒル表記法）:

C₂H₂Cl₂O₂

CAS番号:

79-43-6

分子量:

128.94

UNSPSC Code:

12352106

PubChem Substance ID:

329762686

MDL number:

MFCD00004223

主要文書

すべての文書を表示

スキップする

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

InChI

1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)

SMILES string

OC(=O)C(Cl)Cl

InChI key

JXTHNDFMNIQAHM-UHFFFAOYSA-N

form

liquid

concentration

≤100 ppm in H₂O

bp

110-111 °C

density

0.884 g/mL at 25 °C

Quality Level

100

類似した製品をお探しですか？訪問製品比較ガイド

類似品目との比較

比較内容をすべて表示

相違点を表示

1 of 4

当該品目	D54702	426458	347795
Sigma-Aldrich 707066 DCA Deblock(0.36 M ジクロロ酢酸トルエン溶液)	Sigma-Aldrich D54702 ジクロロ酢酸	Sigma-Aldrich 426458 ジメチルアミン溶液	Sigma-Aldrich 347795 ジクロロ酢酸ナトリウム
concentration ≤100 ppm in H₂O	concentration ≤100%	concentration 38-42% (with HCl, titration), 40 wt. % in H₂O	concentration -
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
form liquid	form liquid	form liquid	form -
density 0.884 g/mL at 25 °C	density 1.563 g/mL at 25 °C (lit.)	density 0.89 g/mL at 25 °C	density -
bp 110-111 °C	bp 194 °C (lit.)	bp -	bp -

Application

DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity.[1]

General description

Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

pictograms

GHS02,GHS08,GHS05,GHS07

signalword

Danger

hcodes

H225,H304,H315,H318,H336,H351,H360FD,H362,H373,H412

pcodes

P210 - P263 - P280 - P301 + P310 - P305 + P351 + P338 - P331

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system

保管分類

3 - Flammable liquids

wgk

WGK 3

flash_point_f

41.0 °F

flash_point_c

5 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents.

A H Krotz et al.

Bioorganic & medicinal chemistry, 7(3), 435-439 (1999-04-29)

It is demonstrated that a solution of dichloroacetic acid in toluene removes dimethoxytrityl groups from the 5'-terminus of an antisense phosphorothioate oligodeoxyribonucleotide (ISIS 5132/CGP69846A) during synthesis on solid support cleanly and efficiently. It is therefore suggested to replace health hazardous

Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents

A H Krotz and D L Cole V T Ravikumar

Bioorganic & Medicinal Chemistry, 7(3), 435-439 (1999)

The contribution of dissolved organic nitrogen and chloramines to nitrogenous disinfection byproduct formation from natural organic matter.

Yi-Hsueh Chuang et al.

Water research, 47(3), 1308-1316 (2013-01-05)

The direct incorporation of chloramines and dissolved organic nitrogen (DON) may provide the nitrogen for nitrogenous disinfection byproducts (N-DBPs). This study explores the contributions of natural DON and chloramine incorporation to the formation of N-DBPs during chloramination. This study also

Investigation of H-bonding and halogen-bonding effects in dichloroacetic acid: DFT calculations of NQR parameters and QTAIM analysis.

Mehdi D Esrafili

Journal of molecular modeling, 18(12), 5005-5016 (2012-06-28)

A theoretical study was performed to examine hydrogen and halogen bonds properties in gas phase and crystalline dichloroacetic acid (DCAA). The specific pattern of O-H∙∙∙O, C-H∙∙∙O, HCl, Cl∙∙∙O and Cl∙∙∙Cl interactions in DCAA dimers is described within the quantum theory

Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.

Alfredo Caro-Maldonado et al.

Journal of immunology (Baltimore, Md. : 1950), 192(8), 3626-3636 (2014-03-13)

B cell activation leads to proliferation and Ab production that can protect from pathogens or promote autoimmunity. Regulation of cell metabolism is essential to support the demands of lymphocyte growth and effector function and may regulate tolerance. In this study

資料

蛍光寿命測定

蛍光寿命測定には、蛍光強度に基づく測定法にない利点があります。応用例として、蛍光寿命分析、蛍光寿命センシングおよび蛍光寿命イメージング（FLI）が挙げられます。

Fluorescence Lifetime Measurement

Fluorescence lifetime measurement is advantageous over intensity-based measurements. Applications include fluorescence lifetime assays, sensing and FLI.

質問

レビュー

評価値なし

アクティブなフィルタ

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

製品に関するお問い合わせはこちら（テクニカルサービス）