1.37171

TWEEN^® 80

high purity, EMPROVE^® EXPERT, Ph. Eur., ChP, JP, NF

• 別名: POE (20) ソルビタンモノオレエート, ポリエチレングリコールソルビタンモノオレアート, ポリオキシエチレンソルビタンモノオレアート, ポリソルベート80
• CAS番号: 9005-65-6
• MDL番号: MFCD00082107
• UNSPSCコード: 12352207
• EC Index Number: 500-019-9

特性

• 由来生物: synthetic
• 品質水準: 500
• グレード: GMP; Halal; Kosher
• 認証: ChP; JP; NF; Ph. Eur.
• 詳細: GMO free; low in endotoxins
• 製品種目: EMPROVE^® EXPERT
• フォーム: liquid
• 有効性: 42200 mg/kg LD₅₀, oral
• 分子量: 1310 g/mol
• 不純物: endotoxins, low
• pH: 5-7 (20 °C, 50 g/L)
• bp: >100 °C
• 密度: 1.07 g/cm³ at 25 °C
• アプリケーション: liquid formulation; parenterals; pharmaceutical; solubility enhancement
• その他の活性: Aflatoxin free
• 保管温度: 15-25°C
• SMILES記法: CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
• InChI: 1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
• InChI Key: RGPBUVUVZKQNHD-MDZDMXLPSA-N

詳細

詳細

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Polysorbate 80 is used to stabilize biomolecule formulations and as solubilizer, emulsifier and wetting agent in small molecule formulations. Polysorbates are known to degrade via autoxidation and hydrolysis. Degradation products can have a negative impact on the stability of the protein as well as the small molecule API. To reduce this risk, the polysorbate high-purity grade contains a low amount of impurities, especially peroxide.

Intended for high-risk applications, this Emprove^® Expert grade contains bioburden and endotoxin limits.

包装

1371710100 / 100ml / glass bottle
1371711000 / 1L / glass bottle

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

TWEEN is a registered trademark of Croda International PLC

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 235.4 °F - closed cup
• 引火点(℃): > 113 °C - closed cup